Identification, analysis and evaluation of human fusion proteins of bacterial origin
172 p.
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| Other Authors: | |
| Format: | Thesis |
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2010
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| Online Access: | https://hdl.handle.net/10356/36052 |
| _version_ | 1826111443742752768 |
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| author | Yu, Yiting |
| author2 | Meena Kishore Sakharkar |
| author_facet | Meena Kishore Sakharkar Yu, Yiting |
| author_sort | Yu, Yiting |
| collection | NTU |
| description | 172 p. |
| first_indexed | 2024-10-01T02:50:48Z |
| format | Thesis |
| id | ntu-10356/36052 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T02:50:48Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/360522023-03-11T17:01:31Z Identification, analysis and evaluation of human fusion proteins of bacterial origin Yu, Yiting Meena Kishore Sakharkar School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering 172 p. Gene fusion is identified as a common phenomenon in the formation of new proteins. In order to better understand this evolutionary trend, we first designed a methodology for the identification of fusion proteins (the composite proteins) consisting of two or more fusion partners (the component proteins). We then applied the designed methodology to identify human fusion proteins of bacterial origin in the human genome. We thus obtained a comprehensive list of 141 putative human composite proteins consisting of component proteins (or domains) of bacterial origin. The 141 identified human fusion proteins were visually inspected and manually mapped to metabolic pathways using the KEGG pathway database interface. We thus selected six fusion proteins that function as metabolic enzymes in the citric acid cycle. DOCTOR OF PHILOSOPHY (MAE) 2010-04-23T02:25:34Z 2010-04-23T02:25:34Z 2007 2007 Thesis Yu, Y. T. (2007). Identification, analysis and evaluation of human fusion proteins of bacterial origin. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/36052 10.32657/10356/36052 application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Yu, Yiting Identification, analysis and evaluation of human fusion proteins of bacterial origin |
| title | Identification, analysis and evaluation of human fusion proteins of bacterial origin |
| title_full | Identification, analysis and evaluation of human fusion proteins of bacterial origin |
| title_fullStr | Identification, analysis and evaluation of human fusion proteins of bacterial origin |
| title_full_unstemmed | Identification, analysis and evaluation of human fusion proteins of bacterial origin |
| title_short | Identification, analysis and evaluation of human fusion proteins of bacterial origin |
| title_sort | identification analysis and evaluation of human fusion proteins of bacterial origin |
| topic | DRNTU::Engineering::Bioengineering |
| url | https://hdl.handle.net/10356/36052 |
| work_keys_str_mv | AT yuyiting identificationanalysisandevaluationofhumanfusionproteinsofbacterialorigin |