Synthetic studies towards bistramide D
Bistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasiti...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | https://hdl.handle.net/10356/38774 |
| _version_ | 1811676757089058816 |
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| author | Kalpana Palani |
| author2 | Roderick Wayland Bates |
| author_facet | Roderick Wayland Bates Kalpana Palani |
| author_sort | Kalpana Palani |
| collection | NTU |
| description | Bistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasitic properties; the recent studies also show that bistramides bind to Actin. Bistramide A was reported to be very potent for the P388/dox, B16, HT29, and NSCLC-N6 cell lines. Bistramide D has similar activity in the NSCLC-N6 cell line but is comparatively less toxic in vivo. There has been no total synthesis of bistramide D reported till now to our knowledge. These intriguing biological profiles and challenging molecular architecture of bistramides motivated us to synthesize bistramide D. |
| first_indexed | 2024-10-01T02:26:32Z |
| format | Thesis |
| id | ntu-10356/38774 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:26:32Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/387742023-02-28T23:32:09Z Synthetic studies towards bistramide D Kalpana Palani Roderick Wayland Bates School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis Bistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasitic properties; the recent studies also show that bistramides bind to Actin. Bistramide A was reported to be very potent for the P388/dox, B16, HT29, and NSCLC-N6 cell lines. Bistramide D has similar activity in the NSCLC-N6 cell line but is comparatively less toxic in vivo. There has been no total synthesis of bistramide D reported till now to our knowledge. These intriguing biological profiles and challenging molecular architecture of bistramides motivated us to synthesize bistramide D. DOCTOR OF PHILOSOPHY (SPMS) 2010-05-18T07:13:15Z 2010-05-18T07:13:15Z 2010 2010 Thesis Kalpana Palani. (2010). Synthetic studies towards bistramide D. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/38774 10.32657/10356/38774 en 199 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis Kalpana Palani Synthetic studies towards bistramide D |
| title | Synthetic studies towards bistramide D |
| title_full | Synthetic studies towards bistramide D |
| title_fullStr | Synthetic studies towards bistramide D |
| title_full_unstemmed | Synthetic studies towards bistramide D |
| title_short | Synthetic studies towards bistramide D |
| title_sort | synthetic studies towards bistramide d |
| topic | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis |
| url | https://hdl.handle.net/10356/38774 |
| work_keys_str_mv | AT kalpanapalani syntheticstudiestowardsbistramided |