Generation of lentiviral-mediated shRNA vectors to inhibit the expression of caspase-1 and Pycard/ASC in dendritic cells.
Dendritic cells (DC) originate from hematopoietic precursors and they detect endogenous and exogenous stimuli which lead to an inflammatory response. The “inflammasome” is a large protein complex which consists of Caspase-1 and Pycard/ASC which are involved in IL-1β and IL-18 processing. However, th...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/10356/39450 |