Continuous separation of a model chiral molecule using a single column process.
A single column chromatography separation of a binary system has been investigated and analyzed. The chiral separation process involved separating Guaifenesin enantiomers using Chiralcel OD as the chiral stationary phase. The desired dimensions of the column were investigated independently through s...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/39525 |
| _version_ | 1811677611463540736 |
|---|---|
| author | Xie, Jun Zhong. |
| author2 | Mohammad Aman Ullah |
| author_facet | Mohammad Aman Ullah Xie, Jun Zhong. |
| author_sort | Xie, Jun Zhong. |
| collection | NTU |
| description | A single column chromatography separation of a binary system has been investigated and analyzed. The chiral separation process involved separating Guaifenesin enantiomers using Chiralcel OD as the chiral stationary phase. The desired dimensions of the column were investigated independently through simulations and the final proposed dimensions were chosen from commercially available column packed with Chiralcel OD. The simulation was done using MatLab and verified with results obtained from reference. The chromatography process was described using Equilibrium dispersive mathematical model and solved numerically using high accuracy Weighted Essentially Non-Oscillatory (WENO) on finite volume scheme. Flow parameters such as volumetric flow rate etc, were also evaluated and a comparison between two methods of determining cycle time were made. |
| first_indexed | 2024-10-01T02:40:07Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/39525 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:40:07Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/395252023-03-03T15:32:16Z Continuous separation of a model chiral molecule using a single column process. Xie, Jun Zhong. Mohammad Aman Ullah School of Chemical and Biomedical Engineering DRNTU::Science::Chemistry::Analytical chemistry::Chromatography A single column chromatography separation of a binary system has been investigated and analyzed. The chiral separation process involved separating Guaifenesin enantiomers using Chiralcel OD as the chiral stationary phase. The desired dimensions of the column were investigated independently through simulations and the final proposed dimensions were chosen from commercially available column packed with Chiralcel OD. The simulation was done using MatLab and verified with results obtained from reference. The chromatography process was described using Equilibrium dispersive mathematical model and solved numerically using high accuracy Weighted Essentially Non-Oscillatory (WENO) on finite volume scheme. Flow parameters such as volumetric flow rate etc, were also evaluated and a comparison between two methods of determining cycle time were made. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2010-05-31T00:42:21Z 2010-05-31T00:42:21Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39525 en Nanyang Technological University 54 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Analytical chemistry::Chromatography Xie, Jun Zhong. Continuous separation of a model chiral molecule using a single column process. |
| title | Continuous separation of a model chiral molecule using a single column process. |
| title_full | Continuous separation of a model chiral molecule using a single column process. |
| title_fullStr | Continuous separation of a model chiral molecule using a single column process. |
| title_full_unstemmed | Continuous separation of a model chiral molecule using a single column process. |
| title_short | Continuous separation of a model chiral molecule using a single column process. |
| title_sort | continuous separation of a model chiral molecule using a single column process |
| topic | DRNTU::Science::Chemistry::Analytical chemistry::Chromatography |
| url | http://hdl.handle.net/10356/39525 |
| work_keys_str_mv | AT xiejunzhong continuousseparationofamodelchiralmoleculeusingasinglecolumnprocess |