Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells
Skin, as the largest body surface exposed to environment, has to protect body from chemical and physical insult, and especially pathogen invasion. In order to avoid any pathogen breaches, the skin has a sophisticated immune system mainly consisting of Langerhans cells (LC) and dendritic epidermal T...
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| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/10356/39546 |
| _version_ | 1811676549559091200 |
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| author | Adi Utama, Diaz |
| author2 | Ruedl Christiane |
| author_facet | Ruedl Christiane Adi Utama, Diaz |
| author_sort | Adi Utama, Diaz |
| collection | NTU |
| description | Skin, as the largest body surface exposed to environment, has to protect body from chemical and physical insult, and especially pathogen invasion. In order to avoid any pathogen breaches, the skin has a sophisticated immune system mainly consisting of Langerhans cells (LC) and dendritic epidermal T cells (DETC). The communication between these cells remains elusive. Therefore, we studied more in depth whether DETC is able mediate LC maturation, and the molecules involved in this communication. We found that LC maturation was mediated by activated DETC. Moreover, GM-CSF was observed to be involved in the DETC-mediated LC maturation. Our results also indicated that there might be other molecules involved as well. Further study is required to delineate the communication between LC and DETC more in details and the molecules involved in the communication. |
| first_indexed | 2024-10-01T02:23:14Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/39546 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:23:14Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/395462023-02-28T18:02:46Z Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells Adi Utama, Diaz Ruedl Christiane School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Immunology Skin, as the largest body surface exposed to environment, has to protect body from chemical and physical insult, and especially pathogen invasion. In order to avoid any pathogen breaches, the skin has a sophisticated immune system mainly consisting of Langerhans cells (LC) and dendritic epidermal T cells (DETC). The communication between these cells remains elusive. Therefore, we studied more in depth whether DETC is able mediate LC maturation, and the molecules involved in this communication. We found that LC maturation was mediated by activated DETC. Moreover, GM-CSF was observed to be involved in the DETC-mediated LC maturation. Our results also indicated that there might be other molecules involved as well. Further study is required to delineate the communication between LC and DETC more in details and the molecules involved in the communication. Bachelor of Science in Biological Sciences 2010-05-31T03:02:32Z 2010-05-31T03:02:32Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39546 en Nanyang Technological University 25 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Immunology Adi Utama, Diaz Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells |
| title | Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells |
| title_full | Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells |
| title_fullStr | Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells |
| title_full_unstemmed | Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells |
| title_short | Understanding the crosstalk among Langerhans cells and dendritic epidermal T cells |
| title_sort | understanding the crosstalk among langerhans cells and dendritic epidermal t cells |
| topic | DRNTU::Science::Biological sciences::Microbiology::Immunology |
| url | http://hdl.handle.net/10356/39546 |
| work_keys_str_mv | AT adiutamadiaz understandingthecrosstalkamonglangerhanscellsanddendriticepidermaltcells |