Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.

Ellman sulfinamide which was first introduced in 1997, is a compound that is highly popular for the synthesis of chiral compounds due to its versatility. In addition, it can be easily introduced on to give the Ellman imine and easily removed from the compound of interest after nucleophilic addition...

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Main Author: Chung, Wan Jun.
Other Authors: School of Physical and Mathematical Sciences
Format: Final Year Project (FYP)
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/39777
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author Chung, Wan Jun.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Chung, Wan Jun.
author_sort Chung, Wan Jun.
collection NTU
description Ellman sulfinamide which was first introduced in 1997, is a compound that is highly popular for the synthesis of chiral compounds due to its versatility. In addition, it can be easily introduced on to give the Ellman imine and easily removed from the compound of interest after nucleophilic addition reaction to give the final desired product. However, the application of the Ellman sulfinamide to the synthesis of highly substituted α-amino acid has not yet been reported. Hence, in this project, several studies towards the synthesis of these highly substituted α-amino acids by first using the Ellman sulfinamide and next, via the formation of hydrazones will be presented.
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spelling ntu-10356/397772023-02-28T23:14:11Z Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A. Chung, Wan Jun. School of Physical and Mathematical Sciences University of Southampton Dr A. Ganesan DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis Ellman sulfinamide which was first introduced in 1997, is a compound that is highly popular for the synthesis of chiral compounds due to its versatility. In addition, it can be easily introduced on to give the Ellman imine and easily removed from the compound of interest after nucleophilic addition reaction to give the final desired product. However, the application of the Ellman sulfinamide to the synthesis of highly substituted α-amino acid has not yet been reported. Hence, in this project, several studies towards the synthesis of these highly substituted α-amino acids by first using the Ellman sulfinamide and next, via the formation of hydrazones will be presented. Bachelor of Science in Chemistry and Biological Chemistry 2010-06-04T02:03:17Z 2010-06-04T02:03:17Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39777 en 74 p. application/pdf
spellingShingle DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Chung, Wan Jun.
Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.
title Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.
title_full Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.
title_fullStr Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.
title_full_unstemmed Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.
title_short Studies on the formation of pyruvate imines and the total synthesis of sanguinamide A.
title_sort studies on the formation of pyruvate imines and the total synthesis of sanguinamide a
topic DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
url http://hdl.handle.net/10356/39777
work_keys_str_mv AT chungwanjun studiesontheformationofpyruvateiminesandthetotalsynthesisofsanguinamidea