Regulation of hypnosis using PID control
Anesthesia implies maintaining a triad of hypnosis, analgesia, and neuromuscular blockade by infusing several drugs which specifically act on each of the above aspects. The hypnosis dynamics of patient can be modeled using a sixth-order nonlinear pharmacokinetic (PK)-pharmacodynamic (PD) model. C...
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| Formato: | Final Year Project (FYP) |
| Idioma: | English |
| Publicado em: |
2010
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| Acesso em linha: | http://hdl.handle.net/10356/40460 |
| _version_ | 1826116067865395200 |
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| author | Wong, Song Jau. |
| author2 | Vinay Kumar Kariwala |
| author_facet | Vinay Kumar Kariwala Wong, Song Jau. |
| author_sort | Wong, Song Jau. |
| collection | NTU |
| description | Anesthesia implies maintaining a triad of hypnosis, analgesia, and neuromuscular
blockade by infusing several drugs which specifically act on each of the above aspects.
The hypnosis dynamics of patient can be modeled using a sixth-order nonlinear
pharmacokinetic (PK)-pharmacodynamic (PD) model. Control systems are desired for
maintaining the hypnosis level to reduce cost and risks. However, due to the nonlinear
nature of PD, the responses obtained from these PD models may be slow. This work
focuses on examining the feasibility of substituting the nonlinearity of pharmacodynamic
models using variable transformation for controlling BIS signal. The closed loop control
strategies of four different PID controller arrangements were compared for both PD
models with and without variable transformation. Robust performance of the four
controllers is tested for a broad range of patients by considering variability in PK-PD
parameters. The relative performance of the four controllers is studied for different
setpoints, noise, and disturbances in BIS signal. It was found that for PI and PID
controller, variable-transformed PD models perform better than nonlinear models. |
| first_indexed | 2024-10-01T04:05:22Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/40460 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:05:22Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/404602023-03-03T15:34:28Z Regulation of hypnosis using PID control Wong, Song Jau. Vinay Kumar Kariwala School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Pharmacy Anesthesia implies maintaining a triad of hypnosis, analgesia, and neuromuscular blockade by infusing several drugs which specifically act on each of the above aspects. The hypnosis dynamics of patient can be modeled using a sixth-order nonlinear pharmacokinetic (PK)-pharmacodynamic (PD) model. Control systems are desired for maintaining the hypnosis level to reduce cost and risks. However, due to the nonlinear nature of PD, the responses obtained from these PD models may be slow. This work focuses on examining the feasibility of substituting the nonlinearity of pharmacodynamic models using variable transformation for controlling BIS signal. The closed loop control strategies of four different PID controller arrangements were compared for both PD models with and without variable transformation. Robust performance of the four controllers is tested for a broad range of patients by considering variability in PK-PD parameters. The relative performance of the four controllers is studied for different setpoints, noise, and disturbances in BIS signal. It was found that for PI and PID controller, variable-transformed PD models perform better than nonlinear models. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2010-06-16T01:06:23Z 2010-06-16T01:06:23Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/40460 en Nanyang Technological University 68 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Pharmacy Wong, Song Jau. Regulation of hypnosis using PID control |
| title | Regulation of hypnosis using PID control |
| title_full | Regulation of hypnosis using PID control |
| title_fullStr | Regulation of hypnosis using PID control |
| title_full_unstemmed | Regulation of hypnosis using PID control |
| title_short | Regulation of hypnosis using PID control |
| title_sort | regulation of hypnosis using pid control |
| topic | DRNTU::Science::Medicine::Pharmacy |
| url | http://hdl.handle.net/10356/40460 |
| work_keys_str_mv | AT wongsongjau regulationofhypnosisusingpidcontrol |