Drug-herb interactions on pseudomonas aeruginosa
The aim of this study was to determine if synergism was observed for various combinations of antibiotics with the phytomedicines against American Type Culture Collection (ATCC) strain of P.aeruginosa. The minimum inhibitory concentration (MIC) of these antibiotics and phytomedicines were de...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/10356/41442 |
| _version_ | 1811687129166643200 |
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| author | Jayaraman Premkumar |
| author2 | Meena Kishore Sakharkar |
| author_facet | Meena Kishore Sakharkar Jayaraman Premkumar |
| author_sort | Jayaraman Premkumar |
| collection | NTU |
| description | The aim of this study was to determine if synergism was observed for various
combinations of antibiotics with the phytomedicines against American Type Culture
Collection (ATCC) strain of P.aeruginosa. The minimum inhibitory concentration
(MIC) of these antibiotics and phytomedicines were determined by microdilution method. The results from both the checkerboard and killing curve methodologies by microdilution method were compared. The results of this study indicate that against P.aeruginosa, synergism is observed in combination with some western antibiotics and phytomedicines. Synergism appears to be maintained even at very high MICs with drug concentrations within achievable therapeutic ranges. With current definitions of synergism there was absolute correlation between the results obtained by the checkerboard and killing curve methodologies, with the fractional inhibitory
concentration indices and killing curves resulting in synergism. No antagonism was
observed. |
| first_indexed | 2024-10-01T05:11:24Z |
| format | Thesis |
| id | ntu-10356/41442 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:11:24Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/414422023-03-11T17:02:24Z Drug-herb interactions on pseudomonas aeruginosa Jayaraman Premkumar Meena Kishore Sakharkar School of Mechanical and Aerospace Engineering BioMedical Engineering Research Centre DRNTU::Science::Medicine::Pharmacy The aim of this study was to determine if synergism was observed for various combinations of antibiotics with the phytomedicines against American Type Culture Collection (ATCC) strain of P.aeruginosa. The minimum inhibitory concentration (MIC) of these antibiotics and phytomedicines were determined by microdilution method. The results from both the checkerboard and killing curve methodologies by microdilution method were compared. The results of this study indicate that against P.aeruginosa, synergism is observed in combination with some western antibiotics and phytomedicines. Synergism appears to be maintained even at very high MICs with drug concentrations within achievable therapeutic ranges. With current definitions of synergism there was absolute correlation between the results obtained by the checkerboard and killing curve methodologies, with the fractional inhibitory concentration indices and killing curves resulting in synergism. No antagonism was observed. Master of Science (Biomedical Engineering) 2010-07-05T04:43:52Z 2010-07-05T04:43:52Z 2008 2008 Thesis http://hdl.handle.net/10356/41442 en 81 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Pharmacy Jayaraman Premkumar Drug-herb interactions on pseudomonas aeruginosa |
| title | Drug-herb interactions on pseudomonas aeruginosa |
| title_full | Drug-herb interactions on pseudomonas aeruginosa |
| title_fullStr | Drug-herb interactions on pseudomonas aeruginosa |
| title_full_unstemmed | Drug-herb interactions on pseudomonas aeruginosa |
| title_short | Drug-herb interactions on pseudomonas aeruginosa |
| title_sort | drug herb interactions on pseudomonas aeruginosa |
| topic | DRNTU::Science::Medicine::Pharmacy |
| url | http://hdl.handle.net/10356/41442 |
| work_keys_str_mv | AT jayaramanpremkumar drugherbinteractionsonpseudomonasaeruginosa |