The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment
Enteric viruses have emerged as important causes of major waterborne disease outbreaks in recent years. The occurrence of enteric viruses in aquatic environments constitutes a major health hazard because of their low infective dose and resistance to environmental breakdown. Currently, our knowledge...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | https://hdl.handle.net/10356/41527 |
| _version_ | 1824454202542260224 |
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| author | Aw, Tiong Gim |
| author2 | Gin Yew-Hoong, Karina |
| author_facet | Gin Yew-Hoong, Karina Aw, Tiong Gim |
| author_sort | Aw, Tiong Gim |
| collection | NTU |
| description | Enteric viruses have emerged as important causes of major waterborne disease outbreaks in recent years. The occurrence of enteric viruses in aquatic environments constitutes a major health hazard because of their low infective dose and resistance to environmental breakdown. Currently, our knowledge on the occurrence of enteric viruses in tropical water environments is limited. This thesis describes the first study of the prevalence and molecular characterization of waterborne pathogenic viruses in urban water catchments and community wastewaters in Singapore. Noroviruses were determined to be the most prevalent enteric viruses detected in both wastewater and surface water samples. Molecular characterization revealed the genetic diversity of astroviruses, enteroviruses and noroviruses in water environments. The norovirus strains detected in environmental samples were closely related to the concurrently identified clinical strains in Singapore during gastroenteritis outbreaks between August 2006 to January 2007. Knowledge on the occurrence of human enteric viruses in water environments contributes to the understanding of the mechanisms of viral transmission and the possible role played by water as a vehicle of transmission. |
| first_indexed | 2025-02-19T03:18:34Z |
| format | Thesis |
| id | ntu-10356/41527 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:18:34Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/415272023-03-03T19:36:49Z The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment Aw, Tiong Gim Gin Yew-Hoong, Karina School of Civil and Environmental Engineering DRNTU::Engineering::Environmental engineering::Water supply Enteric viruses have emerged as important causes of major waterborne disease outbreaks in recent years. The occurrence of enteric viruses in aquatic environments constitutes a major health hazard because of their low infective dose and resistance to environmental breakdown. Currently, our knowledge on the occurrence of enteric viruses in tropical water environments is limited. This thesis describes the first study of the prevalence and molecular characterization of waterborne pathogenic viruses in urban water catchments and community wastewaters in Singapore. Noroviruses were determined to be the most prevalent enteric viruses detected in both wastewater and surface water samples. Molecular characterization revealed the genetic diversity of astroviruses, enteroviruses and noroviruses in water environments. The norovirus strains detected in environmental samples were closely related to the concurrently identified clinical strains in Singapore during gastroenteritis outbreaks between August 2006 to January 2007. Knowledge on the occurrence of human enteric viruses in water environments contributes to the understanding of the mechanisms of viral transmission and the possible role played by water as a vehicle of transmission. Doctor of Philosophy (CEE) 2010-07-16T07:18:29Z 2010-07-16T07:18:29Z 2010 2010 Thesis Aw, T. G. (2010). Occurrence and molecular characterization of enteric viruses in the tropical aquatic environment. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/41527 10.32657/10356/41527 en 224 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Environmental engineering::Water supply Aw, Tiong Gim The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| title | The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| title_full | The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| title_fullStr | The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| title_full_unstemmed | The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| title_short | The occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| title_sort | occurrence and molecular characterization of enteric viruses in the tropical aquatic environment |
| topic | DRNTU::Engineering::Environmental engineering::Water supply |
| url | https://hdl.handle.net/10356/41527 |
| work_keys_str_mv | AT awtionggim theoccurrenceandmolecularcharacterizationofentericvirusesinthetropicalaquaticenvironment AT awtionggim occurrenceandmolecularcharacterizationofentericvirusesinthetropicalaquaticenvironment |