In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents
Our laboratory has been developing a completely biodegradable coronary stent which is made of bi-Iayers of biodegradable polyesters. This thesis presents the investigations carried out to exploit the drug delivery potential of such a polymeric stent. The main objective of this work was to understand...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | https://hdl.handle.net/10356/41732 |
| _version_ | 1826120166267682816 |
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| author | Lao, Luciana Lisa |
| author2 | Subbu S. Venkatraman |
| author_facet | Subbu S. Venkatraman Lao, Luciana Lisa |
| author_sort | Lao, Luciana Lisa |
| collection | NTU |
| description | Our laboratory has been developing a completely biodegradable coronary stent which is made of bi-Iayers of biodegradable polyesters. This thesis presents the investigations carried out to exploit the drug delivery potential of such a polymeric stent. The main objective of this work was to understand and control the release of anti-proliferative drugs from biodegradable polymer films. Such understanding enabled us to explore further the effect of the controlled release of anti-proliferative drug on smooth muscle cell viability. In the bilayer films, an anti-proliferative drug such as paclitaxel is loaded on to the "top" layer that contacts the blood vessel endothelium, while an anti-thrombotic drug such as heparin may be incorporated into the "bottom" of lumen-facing side. Paclitaxel release from P(DL)LGA layer consists of three distinct stages: (i) extremely slow initial release, (ii) accelerated degradative, relaxation-induced release, and (iii) diffusional release. The effect of additives that accelerate release of paclitaxel from P(DL)LGA was studied using in vitro methods. Addition of 10 wt% PEG into P(DL)LGA reduced the induction period by half while replacing P(DL)LGA with PCL resulted in an initial burst followed by a rapid diffusion. |
| first_indexed | 2024-10-01T05:11:44Z |
| format | Thesis |
| id | ntu-10356/41732 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:11:44Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/417322023-03-04T16:47:49Z In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents Lao, Luciana Lisa Subbu S. Venkatraman School of Materials Science & Engineering DRNTU::Engineering::Materials Our laboratory has been developing a completely biodegradable coronary stent which is made of bi-Iayers of biodegradable polyesters. This thesis presents the investigations carried out to exploit the drug delivery potential of such a polymeric stent. The main objective of this work was to understand and control the release of anti-proliferative drugs from biodegradable polymer films. Such understanding enabled us to explore further the effect of the controlled release of anti-proliferative drug on smooth muscle cell viability. In the bilayer films, an anti-proliferative drug such as paclitaxel is loaded on to the "top" layer that contacts the blood vessel endothelium, while an anti-thrombotic drug such as heparin may be incorporated into the "bottom" of lumen-facing side. Paclitaxel release from P(DL)LGA layer consists of three distinct stages: (i) extremely slow initial release, (ii) accelerated degradative, relaxation-induced release, and (iii) diffusional release. The effect of additives that accelerate release of paclitaxel from P(DL)LGA was studied using in vitro methods. Addition of 10 wt% PEG into P(DL)LGA reduced the induction period by half while replacing P(DL)LGA with PCL resulted in an initial burst followed by a rapid diffusion. DOCTOR OF PHILOSOPHY (MSE) 2010-08-05T08:28:47Z 2010-08-05T08:28:47Z 2008 2008 Thesis Lao, L. L. (2008). In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/41732 10.32657/10356/41732 en 192 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials Lao, Luciana Lisa In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents |
| title | In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents |
| title_full | In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents |
| title_fullStr | In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents |
| title_full_unstemmed | In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents |
| title_short | In-vitro drug release from biodegradable matrices : analysis, modeling and application in vascular stents |
| title_sort | in vitro drug release from biodegradable matrices analysis modeling and application in vascular stents |
| topic | DRNTU::Engineering::Materials |
| url | https://hdl.handle.net/10356/41732 |
| work_keys_str_mv | AT laolucianalisa invitrodrugreleasefrombiodegradablematricesanalysismodelingandapplicationinvascularstents |