sFRP1 expression in invasive breast ductal carcinoma.
Introduction: Invasive Ductal Carcinoma (IDC) is the most common form of breast cancers (70-80%). sFRP1 loss has been found in many cancer cell types, including breast cancer. Hence, it is of interest to do a retrospective study to determine whether a correlation exists between the amount of sFRP1 e...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/41741 |
| _version_ | 1826111929679085568 |
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| author | Ong, Daphne Jie Lyn. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Ong, Daphne Jie Lyn. |
| author_sort | Ong, Daphne Jie Lyn. |
| collection | NTU |
| description | Introduction: Invasive Ductal Carcinoma (IDC) is the most common form of breast cancers (70-80%). sFRP1 loss has been found in many cancer cell types, including breast cancer. Hence, it is of interest to do a retrospective study to determine whether a correlation exists between the amount of sFRP1 expression and IDC tumour grade.
Material and Methods: Immunohistochemistry staining was done on 28 IDC cases of 3 cancer grades (8 grade 1, 10 grade 2, 10 grade 3) to detect the amount of sFRP1 protein present. A raw score for each case was obtained from the product of the intensity of the stain (1+, 2+, 3+) and the percentage of cells stained.
Results: Pearson’s test showed that there was no significant correlation between tumour grade and sFRP1 expression. The correlation coefficient was 0.1273 (P=0.5186).
Conclusion: While sFRP1 downregulation of promotes development of IDC, it does not translate to a direct correlation between sFRP1 expression and tumour grade.
Future Direction: sFRP1 can be used in combination as a prognostic marker to develop further epigenetic therapies to counter or reverse the effects of Wnt signaling in IDC (in early detection), while tumour grade can still play a complementary role in determining prognosis of IDC |
| first_indexed | 2024-10-01T02:58:35Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/41741 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:58:35Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/417412023-02-28T18:02:49Z sFRP1 expression in invasive breast ductal carcinoma. Ong, Daphne Jie Lyn. School of Biological Sciences Singapore General Hospital Jabed Iqbal DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology Introduction: Invasive Ductal Carcinoma (IDC) is the most common form of breast cancers (70-80%). sFRP1 loss has been found in many cancer cell types, including breast cancer. Hence, it is of interest to do a retrospective study to determine whether a correlation exists between the amount of sFRP1 expression and IDC tumour grade. Material and Methods: Immunohistochemistry staining was done on 28 IDC cases of 3 cancer grades (8 grade 1, 10 grade 2, 10 grade 3) to detect the amount of sFRP1 protein present. A raw score for each case was obtained from the product of the intensity of the stain (1+, 2+, 3+) and the percentage of cells stained. Results: Pearson’s test showed that there was no significant correlation between tumour grade and sFRP1 expression. The correlation coefficient was 0.1273 (P=0.5186). Conclusion: While sFRP1 downregulation of promotes development of IDC, it does not translate to a direct correlation between sFRP1 expression and tumour grade. Future Direction: sFRP1 can be used in combination as a prognostic marker to develop further epigenetic therapies to counter or reverse the effects of Wnt signaling in IDC (in early detection), while tumour grade can still play a complementary role in determining prognosis of IDC Bachelor of Science in Biomedical Sciences 2010-08-06T06:21:47Z 2010-08-06T06:21:47Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/41741 en Nanyang Technological University 23 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology Ong, Daphne Jie Lyn. sFRP1 expression in invasive breast ductal carcinoma. |
| title | sFRP1 expression in invasive breast ductal carcinoma. |
| title_full | sFRP1 expression in invasive breast ductal carcinoma. |
| title_fullStr | sFRP1 expression in invasive breast ductal carcinoma. |
| title_full_unstemmed | sFRP1 expression in invasive breast ductal carcinoma. |
| title_short | sFRP1 expression in invasive breast ductal carcinoma. |
| title_sort | sfrp1 expression in invasive breast ductal carcinoma |
| topic | DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology |
| url | http://hdl.handle.net/10356/41741 |
| work_keys_str_mv | AT ongdaphnejielyn sfrp1expressionininvasivebreastductalcarcinoma |