Towards the total synthesis of apicularen A
This thesis involves the synthesis of an intermediate towards Apicularen A utilizing indium-mediated conjugate addition of a thioester derived ketene to a conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential for its bioactivity as a potential anti-cancer agent.
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| Format: | Thesis |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/41762 |
| Summary: | This thesis involves the synthesis of an intermediate towards Apicularen A
utilizing indium-mediated conjugate addition of a thioester derived ketene to a
conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential
for its bioactivity as a potential anti-cancer agent. |
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