Turning on/off death switch molecule puma
Retroviruses produce few proteins (10 to 15 in most cases), and yet they can manipulate the host replication machinery for its survival advantages. In the current project period, we used coronavirus as a tool and were able to advance our understanding of viral-host interactions. We demonstrated how...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Research Report |
| Language: | English |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/41877 |
| _version_ | 1811685257390325760 |
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| author | P. Tam, James Li, Frank Qisheng Wang, Li Liao, Ying Yuan, Quan. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences P. Tam, James Li, Frank Qisheng Wang, Li Liao, Ying Yuan, Quan. |
| author_sort | P. Tam, James |
| collection | NTU |
| description | Retroviruses produce few proteins (10 to 15 in most cases), and yet they can manipulate the host replication machinery for its survival advantages. In the current project period, we used coronavirus as a tool and were able to advance our understanding of viral-host interactions. We demonstrated how certain viral proteins manipulate the host cellular machinery and how viral proteins
modulate apoptosis, cell cycle progression, and mitogenic growth. These results provide insights to cell signaling mechanism and protein-protein interactions that are fundamentally important to the understanding of infection and pathophysiology of disease. |
| first_indexed | 2024-10-01T04:41:39Z |
| format | Research Report |
| id | ntu-10356/41877 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:41:39Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/418772023-02-28T17:58:22Z Turning on/off death switch molecule puma P. Tam, James Li, Frank Qisheng Wang, Li Liao, Ying Yuan, Quan. School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Virology Retroviruses produce few proteins (10 to 15 in most cases), and yet they can manipulate the host replication machinery for its survival advantages. In the current project period, we used coronavirus as a tool and were able to advance our understanding of viral-host interactions. We demonstrated how certain viral proteins manipulate the host cellular machinery and how viral proteins modulate apoptosis, cell cycle progression, and mitogenic growth. These results provide insights to cell signaling mechanism and protein-protein interactions that are fundamentally important to the understanding of infection and pathophysiology of disease. ARC 4/05 2010-08-27T06:05:37Z 2010-08-27T06:05:37Z 2008 2008 Research Report http://hdl.handle.net/10356/41877 en 12 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Virology P. Tam, James Li, Frank Qisheng Wang, Li Liao, Ying Yuan, Quan. Turning on/off death switch molecule puma |
| title | Turning on/off death switch molecule puma |
| title_full | Turning on/off death switch molecule puma |
| title_fullStr | Turning on/off death switch molecule puma |
| title_full_unstemmed | Turning on/off death switch molecule puma |
| title_short | Turning on/off death switch molecule puma |
| title_sort | turning on off death switch molecule puma |
| topic | DRNTU::Science::Biological sciences::Microbiology::Virology |
| url | http://hdl.handle.net/10356/41877 |
| work_keys_str_mv | AT ptamjames turningonoffdeathswitchmoleculepuma AT lifrankqisheng turningonoffdeathswitchmoleculepuma AT wangli turningonoffdeathswitchmoleculepuma AT liaoying turningonoffdeathswitchmoleculepuma AT yuanquan turningonoffdeathswitchmoleculepuma |