Mechanism of polymorphism for pharmaceutical crystallization
The objectives of this work are to investigate the mechanism and progression of polymorphic transformation and crystallization, study the effect of additives, solvents, and experimental conditions, and develop effective polymorph controlling strategy for pharmaceutical manufacture. The nucleation an...
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| Format: | Research Report |
| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/10356/42259 |
| _version_ | 1826124768722550784 |
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| author | Ching, Chi Bun |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Ching, Chi Bun |
| author_sort | Ching, Chi Bun |
| collection | NTU |
| description | The objectives of this work are to investigate the mechanism and progression of polymorphic transformation and crystallization, study the effect of additives, solvents, and experimental conditions, and develop effective polymorph controlling strategy for pharmaceutical manufacture. The nucleation and transformation of two polymorphs of glycine (α- and γ-forms) have been investigated. The influence of additive, solvent and process parameters such as saturated temperature, seed size and stirring speed on the transformation behavior from metastable form to stable form were examined. The different polymorphs were unambiguously examined by using Powder XRD, Raman microscope, FTIR, TGA and DSC. The polymorphic transition temperature was determined by both DSC and solubility measurements. The in-situ Raman spectroscopy was used to monitor the polymorphic transformation process and the solid-phase polymorphic composition was quantitatively calculated using multivariate analysis. The polymorphic transformation in solvent was also in-situ inspected using microscope with heating/cooling stage. The integration of the different off-line and in-situ measurement and controlling techniques will be valuable in studying the crystallization and transformation mechanism of polymorphic systems and developing a robust crystallization process to obtain the desired polymorphic crystal products. |
| first_indexed | 2024-10-01T06:25:46Z |
| format | Research Report |
| id | ntu-10356/42259 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:25:46Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/422592023-03-03T15:30:38Z Mechanism of polymorphism for pharmaceutical crystallization Ching, Chi Bun School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology The objectives of this work are to investigate the mechanism and progression of polymorphic transformation and crystallization, study the effect of additives, solvents, and experimental conditions, and develop effective polymorph controlling strategy for pharmaceutical manufacture. The nucleation and transformation of two polymorphs of glycine (α- and γ-forms) have been investigated. The influence of additive, solvent and process parameters such as saturated temperature, seed size and stirring speed on the transformation behavior from metastable form to stable form were examined. The different polymorphs were unambiguously examined by using Powder XRD, Raman microscope, FTIR, TGA and DSC. The polymorphic transition temperature was determined by both DSC and solubility measurements. The in-situ Raman spectroscopy was used to monitor the polymorphic transformation process and the solid-phase polymorphic composition was quantitatively calculated using multivariate analysis. The polymorphic transformation in solvent was also in-situ inspected using microscope with heating/cooling stage. The integration of the different off-line and in-situ measurement and controlling techniques will be valuable in studying the crystallization and transformation mechanism of polymorphic systems and developing a robust crystallization process to obtain the desired polymorphic crystal products. RG48/05 2010-10-06T03:17:41Z 2010-10-06T03:17:41Z 2007 2007 Research Report http://hdl.handle.net/10356/42259 en 24 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology Ching, Chi Bun Mechanism of polymorphism for pharmaceutical crystallization |
| title | Mechanism of polymorphism for pharmaceutical crystallization |
| title_full | Mechanism of polymorphism for pharmaceutical crystallization |
| title_fullStr | Mechanism of polymorphism for pharmaceutical crystallization |
| title_full_unstemmed | Mechanism of polymorphism for pharmaceutical crystallization |
| title_short | Mechanism of polymorphism for pharmaceutical crystallization |
| title_sort | mechanism of polymorphism for pharmaceutical crystallization |
| topic | DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology |
| url | http://hdl.handle.net/10356/42259 |
| work_keys_str_mv | AT chingchibun mechanismofpolymorphismforpharmaceuticalcrystallization |