Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1)
The p53 tumour suppressor protein plays a pivotal role in coordinating the cellular response to a range of environmental and intracellular stresses. Multiple stress signals that activate p53 include hypoxia, telomere erosion, oncogenes and DNA damage, which is the best studied of them all. Activated...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/42360 |
| _version_ | 1811679810868477952 |
|---|---|
| author | Nam, Shin Yuen |
| author2 | Koh Cheng Gee |
| author_facet | Koh Cheng Gee Nam, Shin Yuen |
| author_sort | Nam, Shin Yuen |
| collection | NTU |
| description | The p53 tumour suppressor protein plays a pivotal role in coordinating the cellular response to a range of environmental and intracellular stresses. Multiple stress signals that activate p53 include hypoxia, telomere erosion, oncogenes and DNA damage, which is the best studied of them all. Activated p53 translocates into the nucleus and acts as a transcription factor to regulate its target genes, resulting in the anti-proliferative affects of p53 like cell cycle arrest, apoptosis, and DNA repair. The functions of p53 are regulated by several mechanisms including post-translation modifications, protein-protein interaction, etc. |
| first_indexed | 2024-10-01T03:15:05Z |
| format | Thesis |
| id | ntu-10356/42360 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:15:05Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/423602023-02-28T18:33:50Z Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) Nam, Shin Yuen Koh Cheng Gee School of Biological Sciences Kanaga Sabapathy DRNTU::Science::Biological sciences::Molecular biology The p53 tumour suppressor protein plays a pivotal role in coordinating the cellular response to a range of environmental and intracellular stresses. Multiple stress signals that activate p53 include hypoxia, telomere erosion, oncogenes and DNA damage, which is the best studied of them all. Activated p53 translocates into the nucleus and acts as a transcription factor to regulate its target genes, resulting in the anti-proliferative affects of p53 like cell cycle arrest, apoptosis, and DNA repair. The functions of p53 are regulated by several mechanisms including post-translation modifications, protein-protein interaction, etc. Doctor of Philosophy (SBS) 2010-11-11T01:12:03Z 2010-11-11T01:12:03Z 2010 2010 Thesis http://hdl.handle.net/10356/42360 en 149 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Molecular biology Nam, Shin Yuen Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) |
| title | Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) |
| title_full | Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) |
| title_fullStr | Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) |
| title_full_unstemmed | Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) |
| title_short | Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) |
| title_sort | characterization of a novel p53 target gene heme oxygenase decycling 1 hmox1 |
| topic | DRNTU::Science::Biological sciences::Molecular biology |
| url | http://hdl.handle.net/10356/42360 |
| work_keys_str_mv | AT namshinyuen characterizationofanovelp53targetgenehemeoxygenasedecycling1hmox1 |