Investigation of anticancer agent and high mobility group N protein binding to nucleosomes.
By influencing nuclear factor recognition through modulation of double helix conformation and context, nucleosome structure and organization are key to understanding genomic regulation and the activity of DNA-binding medicinal agents. DNA stretching in the nucleosome, coinciding with kinking and in...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/10356/42387 |