Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein
The small hydrophobic (SH) protein is a transmembrane surface glycoprotein encoded by the respiratory syncytial virus (RSV). It is 64 amino acids long with one putative transmembrane domain. Although SH protein is important for viral infectivity, its exact role during viral infection is not clear. I...
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| Format: | Thesis |
| Language: | English |
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2011
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| Online Access: | https://hdl.handle.net/10356/42676 |
| _version_ | 1811689521253711872 |
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| author | Gan, Siok Wan |
| author2 | Jaume Torres |
| author_facet | Jaume Torres Gan, Siok Wan |
| author_sort | Gan, Siok Wan |
| collection | NTU |
| description | The small hydrophobic (SH) protein is a transmembrane surface glycoprotein encoded by the respiratory syncytial virus (RSV). It is 64 amino acids long with one putative transmembrane domain. Although SH protein is important for viral infectivity, its exact role during viral infection is not clear. In this study, we have examined the structure, oligomerization, and function of SH protein and the transmembrane domain (SH-TM) using biochemical, biophysical and computational approaches. |
| first_indexed | 2024-10-01T05:49:25Z |
| format | Thesis |
| id | ntu-10356/42676 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:49:25Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/426762023-02-28T18:42:04Z Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein Gan, Siok Wan Jaume Torres School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Virology The small hydrophobic (SH) protein is a transmembrane surface glycoprotein encoded by the respiratory syncytial virus (RSV). It is 64 amino acids long with one putative transmembrane domain. Although SH protein is important for viral infectivity, its exact role during viral infection is not clear. In this study, we have examined the structure, oligomerization, and function of SH protein and the transmembrane domain (SH-TM) using biochemical, biophysical and computational approaches. DOCTOR OF PHILOSOPHY (SBS) 2011-01-07T01:15:32Z 2011-01-07T01:15:32Z 2010 2010 Thesis Gan, S. W. (2010). Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/42676 10.32657/10356/42676 en 141 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Virology Gan, Siok Wan Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| title | Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| title_full | Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| title_fullStr | Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| title_full_unstemmed | Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| title_short | Structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| title_sort | structural and functional characterization of the human respiratory syncytial virus small hydrophobic protein |
| topic | DRNTU::Science::Biological sciences::Microbiology::Virology |
| url | https://hdl.handle.net/10356/42676 |
| work_keys_str_mv | AT gansiokwan structuralandfunctionalcharacterizationofthehumanrespiratorysyncytialvirussmallhydrophobicprotein |