A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities
A novel drug delivery system consisting of drug-loaded microparticles encapsulated within larger hollow microcapsules had been devised. The novelty of this system is that microparticles can simultaneously be loaded with multiple drug types before being packed into a single microsphere. To demonstr...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/10356/44249 |
| _version_ | 1811695462017662976 |
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| author | Chui, Kit Leong. |
| author2 | Loo Say Chye Joachim |
| author_facet | Loo Say Chye Joachim Chui, Kit Leong. |
| author_sort | Chui, Kit Leong. |
| collection | NTU |
| description | A novel drug delivery system consisting of drug-loaded microparticles encapsulated within larger hollow microcapsules had been devised. The novelty of this system is that microparticles can simultaneously be loaded with multiple drug types before being packed into a single microsphere. To demonstrate the feasibility of the proposed system, the system was fabricated through a modified two step O/W/O/W solvent emulsion technique. Poly (L-lactic acid) (PLLA) microparticles were first fabricated separately with two different flurophores, Coumarin 6 and Rhodamine 6G respectively. The flurophore-dye loaded PLLA microparticles were then mixed together and subsequently entrapped within degradable Poly [(D,L-lactide)-co-glycolide] (PLGA) microcapsules. SEM, Confocal and FTIR results had shown that fluorophore-loaded microparticles were successfully incorporated into a single hollow microcapsule. Ibuprofen was then loaded into the PLLA microparticles before encapsulation by the PLGA microcapsule to validate the capability of the system for drug hosting and delivery. |
| first_indexed | 2024-10-01T07:23:51Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/44249 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:23:51Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/442492023-03-04T15:37:34Z A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities Chui, Kit Leong. Loo Say Chye Joachim School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials A novel drug delivery system consisting of drug-loaded microparticles encapsulated within larger hollow microcapsules had been devised. The novelty of this system is that microparticles can simultaneously be loaded with multiple drug types before being packed into a single microsphere. To demonstrate the feasibility of the proposed system, the system was fabricated through a modified two step O/W/O/W solvent emulsion technique. Poly (L-lactic acid) (PLLA) microparticles were first fabricated separately with two different flurophores, Coumarin 6 and Rhodamine 6G respectively. The flurophore-dye loaded PLLA microparticles were then mixed together and subsequently entrapped within degradable Poly [(D,L-lactide)-co-glycolide] (PLGA) microcapsules. SEM, Confocal and FTIR results had shown that fluorophore-loaded microparticles were successfully incorporated into a single hollow microcapsule. Ibuprofen was then loaded into the PLLA microparticles before encapsulation by the PLGA microcapsule to validate the capability of the system for drug hosting and delivery. Bachelor of Engineering (Materials Engineering) 2011-05-31T07:04:09Z 2011-05-31T07:04:09Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/44249 en Nanyang Technological University 44 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Biomaterials Chui, Kit Leong. A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities |
| title | A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities |
| title_full | A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities |
| title_fullStr | A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities |
| title_full_unstemmed | A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities |
| title_short | A polymeric microencapsulation approach for the simultaneous entrapment of multi-chemical entities |
| title_sort | polymeric microencapsulation approach for the simultaneous entrapment of multi chemical entities |
| topic | DRNTU::Engineering::Materials::Biomaterials |
| url | http://hdl.handle.net/10356/44249 |
| work_keys_str_mv | AT chuikitleong apolymericmicroencapsulationapproachforthesimultaneousentrapmentofmultichemicalentities AT chuikitleong polymericmicroencapsulationapproachforthesimultaneousentrapmentofmultichemicalentities |