Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.
MVIIA is a peptide isolated from cone snail venom. It is a potent inhibitor of N-type voltage-gated calcium channels on presynaptic neurons, preventing release of neurotransmitters for pain signal transmission. Its synthetic form Ziconotide has been approved for clinical therapy but can only be admi...
Main Author: | Koh, Samantha Qian Ping. |
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Other Authors: | Jimmy Pingkwan Tam @ James P Tam |
Format: | Final Year Project (FYP) |
Language: | English |
Published: |
2011
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Subjects: | |
Online Access: | http://hdl.handle.net/10356/44537 |
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