A vaccination strategy to prevent experimental cerebral malaria.
Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) induces a syndrome called experimental cerebral malaria (ECM) in mice, commonly used as a model to study cerebral malaria (CM) in humans, a major complication of Plasmodium falciparum infection. In this study we showed that immunization of...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2011
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| Online Access: | http://hdl.handle.net/10356/45106 |
| _version_ | 1826123692240797696 |
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| author | Ong, Joanne Wei En. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Ong, Joanne Wei En. |
| author_sort | Ong, Joanne Wei En. |
| collection | NTU |
| description | Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) induces a syndrome called experimental cerebral malaria (ECM) in mice, commonly used as a model to study cerebral malaria (CM) in humans, a major complication of Plasmodium falciparum infection. In this study we showed that immunization of C57BL/6 mice with live erythrocytes infected with PbA under chloroquine cover confers a partial protection against blood stage infection. This protection is mediated by antibodies. Although immunization was able to induce a reduction of parasitemia in peripheral blood and a decrease of parasite sequestration in the brain at the time of ECM onset, T cells sequestration in the brain remained unchanged and immunization did not prevent the occurrence of ECM. These findings have provided new insights into the possible prevention of CM through appropriate vaccination. |
| first_indexed | 2024-10-01T06:08:28Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/45106 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:08:28Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/451062023-02-28T17:59:53Z A vaccination strategy to prevent experimental cerebral malaria. Ong, Joanne Wei En. School of Biological Sciences A*STAR Singapore Immunology Network Laurent Rénia Marjorie Mauduit DRNTU::Science::Biological sciences::Microbiology::Immunology Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) induces a syndrome called experimental cerebral malaria (ECM) in mice, commonly used as a model to study cerebral malaria (CM) in humans, a major complication of Plasmodium falciparum infection. In this study we showed that immunization of C57BL/6 mice with live erythrocytes infected with PbA under chloroquine cover confers a partial protection against blood stage infection. This protection is mediated by antibodies. Although immunization was able to induce a reduction of parasitemia in peripheral blood and a decrease of parasite sequestration in the brain at the time of ECM onset, T cells sequestration in the brain remained unchanged and immunization did not prevent the occurrence of ECM. These findings have provided new insights into the possible prevention of CM through appropriate vaccination. Bachelor of Science in Biological Sciences 2011-06-09T02:59:32Z 2011-06-09T02:59:32Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45106 en Nanyang Technological University 31 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Immunology Ong, Joanne Wei En. A vaccination strategy to prevent experimental cerebral malaria. |
| title | A vaccination strategy to prevent experimental cerebral malaria. |
| title_full | A vaccination strategy to prevent experimental cerebral malaria. |
| title_fullStr | A vaccination strategy to prevent experimental cerebral malaria. |
| title_full_unstemmed | A vaccination strategy to prevent experimental cerebral malaria. |
| title_short | A vaccination strategy to prevent experimental cerebral malaria. |
| title_sort | vaccination strategy to prevent experimental cerebral malaria |
| topic | DRNTU::Science::Biological sciences::Microbiology::Immunology |
| url | http://hdl.handle.net/10356/45106 |
| work_keys_str_mv | AT ongjoanneweien avaccinationstrategytopreventexperimentalcerebralmalaria AT ongjoanneweien vaccinationstrategytopreventexperimentalcerebralmalaria |