Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models
Breast cancer is a type of cancer originating from the breast tissue due to DNA mutations that cause normal breast cells to divide uncontrollably and become cancerous. Today, breast cancer is one of the most commonly occurring cancers in women. Hence, advanced research is being conducted on various...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/45152 |
| _version_ | 1826130346433839104 |
|---|---|
| author | Adhylakshumie Adhynarayanan |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Adhylakshumie Adhynarayanan |
| author_sort | Adhylakshumie Adhynarayanan |
| collection | NTU |
| description | Breast cancer is a type of cancer originating from the breast tissue due to DNA mutations that cause normal breast cells to divide uncontrollably and become cancerous. Today, breast cancer is one of the most commonly occurring cancers in women. Hence, advanced research is being conducted on various breast cancer cell lines with hopes of discovering significant improvements in breast cancer treatments.
This report illustrates the final year project on the generation of a stable breast cancer cell line of BT474-biosensor. BT474 breast cancer cell line overexpresses human epidermal growth factor receptor 2 (HER2) which causes tumour cells to grow much more rapidly and to be more aggressive, hence increasing its metastatic ability. As such, tracking the metastasis of human breast cancer cells and examining the effect of new anticancer drugs with a stable BT474-biosensor cell line generated, using animal models, would provide key findings in the study and treatment of metastatic breast cancer. |
| first_indexed | 2024-10-01T07:54:58Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/45152 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:54:58Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/451522023-03-03T15:40:01Z Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models Adhylakshumie Adhynarayanan School of Chemical and Biomedical Engineering Luo Qian Kathy DRNTU::Science::Medicine::Biosensors Breast cancer is a type of cancer originating from the breast tissue due to DNA mutations that cause normal breast cells to divide uncontrollably and become cancerous. Today, breast cancer is one of the most commonly occurring cancers in women. Hence, advanced research is being conducted on various breast cancer cell lines with hopes of discovering significant improvements in breast cancer treatments. This report illustrates the final year project on the generation of a stable breast cancer cell line of BT474-biosensor. BT474 breast cancer cell line overexpresses human epidermal growth factor receptor 2 (HER2) which causes tumour cells to grow much more rapidly and to be more aggressive, hence increasing its metastatic ability. As such, tracking the metastasis of human breast cancer cells and examining the effect of new anticancer drugs with a stable BT474-biosensor cell line generated, using animal models, would provide key findings in the study and treatment of metastatic breast cancer. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2011-06-09T06:41:33Z 2011-06-09T06:41:33Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45152 en Nanyang Technological University 80 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Biosensors Adhylakshumie Adhynarayanan Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models |
| title | Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models |
| title_full | Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models |
| title_fullStr | Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models |
| title_full_unstemmed | Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models |
| title_short | Generating a stable cell line of BT474-biosensor for tracking the metastasis of human breast cancer cells in animal models |
| title_sort | generating a stable cell line of bt474 biosensor for tracking the metastasis of human breast cancer cells in animal models |
| topic | DRNTU::Science::Medicine::Biosensors |
| url | http://hdl.handle.net/10356/45152 |
| work_keys_str_mv | AT adhylakshumieadhynarayanan generatingastablecelllineofbt474biosensorfortrackingthemetastasisofhumanbreastcancercellsinanimalmodels |