Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum.
Plasmodium falciparum is the most lethal species of the Plasmodium genus. Epigenetic regulation is one of the key regulations that enable parasites to perform rapid transitions throughout their lifecycle and antigenic variations to sustain chronic infections. Using ChIP-on-chip, we studied Post-tran...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2011
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| Online Access: | http://hdl.handle.net/10356/45266 |
| _version_ | 1824457072873308160 |
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| author | Tan, Corinna Cailing. |
| author2 | Zbynek Bozdech |
| author_facet | Zbynek Bozdech Tan, Corinna Cailing. |
| author_sort | Tan, Corinna Cailing. |
| collection | NTU |
| description | Plasmodium falciparum is the most lethal species of the Plasmodium genus. Epigenetic regulation is one of the key regulations that enable parasites to perform rapid transitions throughout their lifecycle and antigenic variations to sustain chronic infections. Using ChIP-on-chip, we studied Post-translational modification (Acetylation) on core histone H4- lysine 8 (H4K8ac) and lysine 16 (H4K16ac) on P. falciparum strain Dd2 and Tetra-acetylation (H4ac4) for another P. falciparum strain 3D7. We also observed the enrichment of these modifications on certain genes across the intraerythrocytic developmental cycle (IDC) of the parasite. A bimodal distribution in the correlations between enrichment and their corresponding expression profiles of all modifications, showing the modulation of gene expression. It was suggested that epigenetic regulation could take place more within intragenic regions than intergenic regions. Interestingly, the comparison between the two different P. falciparum strains of H4K8ac and H4K16ac modification showed similarity in gene enrichment and functional enrichment analysis gave greater insights into the physiological relevance of these epigenetic modifications. |
| first_indexed | 2025-02-19T04:04:11Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/45266 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T04:04:11Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/452662023-02-28T18:06:59Z Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. Tan, Corinna Cailing. Zbynek Bozdech School of Biological Sciences Archna P. Gupta DRNTU::Science::Biological sciences::Microbiology::Microorganisms Plasmodium falciparum is the most lethal species of the Plasmodium genus. Epigenetic regulation is one of the key regulations that enable parasites to perform rapid transitions throughout their lifecycle and antigenic variations to sustain chronic infections. Using ChIP-on-chip, we studied Post-translational modification (Acetylation) on core histone H4- lysine 8 (H4K8ac) and lysine 16 (H4K16ac) on P. falciparum strain Dd2 and Tetra-acetylation (H4ac4) for another P. falciparum strain 3D7. We also observed the enrichment of these modifications on certain genes across the intraerythrocytic developmental cycle (IDC) of the parasite. A bimodal distribution in the correlations between enrichment and their corresponding expression profiles of all modifications, showing the modulation of gene expression. It was suggested that epigenetic regulation could take place more within intragenic regions than intergenic regions. Interestingly, the comparison between the two different P. falciparum strains of H4K8ac and H4K16ac modification showed similarity in gene enrichment and functional enrichment analysis gave greater insights into the physiological relevance of these epigenetic modifications. Bachelor of Science in Biological Sciences 2011-06-10T06:21:02Z 2011-06-10T06:21:02Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45266 en Nanyang Technological University 31 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Microorganisms Tan, Corinna Cailing. Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. |
| title | Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. |
| title_full | Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. |
| title_fullStr | Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. |
| title_full_unstemmed | Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. |
| title_short | Epigenetic regulation of gene expression in human malaria parasite Plasmodium falciparum. |
| title_sort | epigenetic regulation of gene expression in human malaria parasite plasmodium falciparum |
| topic | DRNTU::Science::Biological sciences::Microbiology::Microorganisms |
| url | http://hdl.handle.net/10356/45266 |
| work_keys_str_mv | AT tancorinnacailing epigeneticregulationofgeneexpressioninhumanmalariaparasiteplasmodiumfalciparum |