Fabrication of micro-and nano-particles of drug for pharmaceutical application (I)
This project aims to improve the solubility of a poorly-water soluble drug, Hesperetin, by fabricating the drug into mico-/nano- particles. Fabrication of the drug particles was done using the two approaches, namely syringe pump precipitation approach and evaporative precipitation of nano-suspension...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/45322 |
| _version_ | 1811676386562146304 |
|---|---|
| author | Tan, Yong Wah. |
| author2 | Li Lin |
| author_facet | Li Lin Tan, Yong Wah. |
| author_sort | Tan, Yong Wah. |
| collection | NTU |
| description | This project aims to improve the solubility of a poorly-water soluble drug, Hesperetin, by fabricating the drug into mico-/nano- particles. Fabrication of the drug particles was done using the two approaches, namely syringe pump precipitation approach and evaporative precipitation of nano-suspension (EPN) respectively; the physiochemical properties of all the samples fabricated has been investigated.
For this project, various operation parameters, such as drug concentration, flow rate, stirring rate, solvent and anti-solvent ratio (SAS ratio) and temperature were varied and their influence on the drug were experimentally investigated. Apart from that, solid dispersion was made on Hesperetin by adding hydrophilic carriers such as polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Further studies were carried out to improve Hesperetin solubility, through samples’ fabrication with addition of surfactants such as Pluronic 38, Tween 20, Tween 80, etc, into the HSP-PVP and HSP-PEG to form ternary complexes. |
| first_indexed | 2024-10-01T02:20:39Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/45322 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:20:39Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/453222023-03-04T18:19:18Z Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) Tan, Yong Wah. Li Lin School of Mechanical and Aerospace Engineering DRNTU::Engineering::Materials::Nanostructured materials This project aims to improve the solubility of a poorly-water soluble drug, Hesperetin, by fabricating the drug into mico-/nano- particles. Fabrication of the drug particles was done using the two approaches, namely syringe pump precipitation approach and evaporative precipitation of nano-suspension (EPN) respectively; the physiochemical properties of all the samples fabricated has been investigated. For this project, various operation parameters, such as drug concentration, flow rate, stirring rate, solvent and anti-solvent ratio (SAS ratio) and temperature were varied and their influence on the drug were experimentally investigated. Apart from that, solid dispersion was made on Hesperetin by adding hydrophilic carriers such as polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Further studies were carried out to improve Hesperetin solubility, through samples’ fabrication with addition of surfactants such as Pluronic 38, Tween 20, Tween 80, etc, into the HSP-PVP and HSP-PEG to form ternary complexes. Bachelor of Engineering (Mechanical Engineering) 2011-06-13T00:53:46Z 2011-06-13T00:53:46Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45322 en Nanyang Technological University 90 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Nanostructured materials Tan, Yong Wah. Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) |
| title | Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) |
| title_full | Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) |
| title_fullStr | Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) |
| title_full_unstemmed | Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) |
| title_short | Fabrication of micro-and nano-particles of drug for pharmaceutical application (I) |
| title_sort | fabrication of micro and nano particles of drug for pharmaceutical application i |
| topic | DRNTU::Engineering::Materials::Nanostructured materials |
| url | http://hdl.handle.net/10356/45322 |
| work_keys_str_mv | AT tanyongwah fabricationofmicroandnanoparticlesofdrugforpharmaceuticalapplicationi |