Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy.
The report presents the development and optimization of a new class of Surface Enhanced Raman Scattering (SERS) based optical fiber sensing platform known as metal-film over nanospheres (MFON) SERS active fiber. It involved deposition of polystyrene (PS) nanospheres, followed by silver (Ag) film coa...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/10356/45412 |
| _version_ | 1824455620105863168 |
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| author | Low, Vway Hau. |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Low, Vway Hau. |
| author_sort | Low, Vway Hau. |
| collection | NTU |
| description | The report presents the development and optimization of a new class of Surface Enhanced Raman Scattering (SERS) based optical fiber sensing platform known as metal-film over nanospheres (MFON) SERS active fiber. It involved deposition of polystyrene (PS) nanospheres, followed by silver (Ag) film coating. Morphological characterization of the SERS active surfaces was conducted using Scanning Electron Microscopy (SEM) and the SERS performances of the fibers were evaluated by studying the signal intensity measured from analyte molecules through a backscattering geometry. Through a comparative analysis, the novel MFON SERS active fiber was proved to have SERS enhancement ability of 25 fold more than the reported gold nanoparticles immobilized SERS active fiber. Two novel methods have been proposed to deposit the PS nanospheres monolayer on the fiber tip, including a simple ‘dip and dry’ method and PS nanospheres anchoring using chemical method. Optimization of the SERS active fibers was done by varying the PS size, PS concentration and Ag film thickness to search for the best configuration that is able to contribute to high SERS enhancement at the same time achieve a good sample-to-sample reproducibility. |
| first_indexed | 2025-02-19T03:41:06Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/45412 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:41:06Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/454122023-03-03T15:41:01Z Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. Low, Vway Hau. School of Chemical and Biomedical Engineering A*STAR Singapore Bioimaging Consortium Duan Hongwei DRNTU::Engineering::Nanotechnology DRNTU::Science::Physics::Optics and light The report presents the development and optimization of a new class of Surface Enhanced Raman Scattering (SERS) based optical fiber sensing platform known as metal-film over nanospheres (MFON) SERS active fiber. It involved deposition of polystyrene (PS) nanospheres, followed by silver (Ag) film coating. Morphological characterization of the SERS active surfaces was conducted using Scanning Electron Microscopy (SEM) and the SERS performances of the fibers were evaluated by studying the signal intensity measured from analyte molecules through a backscattering geometry. Through a comparative analysis, the novel MFON SERS active fiber was proved to have SERS enhancement ability of 25 fold more than the reported gold nanoparticles immobilized SERS active fiber. Two novel methods have been proposed to deposit the PS nanospheres monolayer on the fiber tip, including a simple ‘dip and dry’ method and PS nanospheres anchoring using chemical method. Optimization of the SERS active fibers was done by varying the PS size, PS concentration and Ag film thickness to search for the best configuration that is able to contribute to high SERS enhancement at the same time achieve a good sample-to-sample reproducibility. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2011-06-13T07:06:34Z 2011-06-13T07:06:34Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45412 en Nanyang Technological University 82 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Nanotechnology DRNTU::Science::Physics::Optics and light Low, Vway Hau. Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. |
| title | Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. |
| title_full | Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. |
| title_fullStr | Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. |
| title_full_unstemmed | Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. |
| title_short | Development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced Raman spectroscopy. |
| title_sort | development and optimization of polystyrene nanoparticle templated optical fiber platform for in vivo surface enhanced raman spectroscopy |
| topic | DRNTU::Engineering::Nanotechnology DRNTU::Science::Physics::Optics and light |
| url | http://hdl.handle.net/10356/45412 |
| work_keys_str_mv | AT lowvwayhau developmentandoptimizationofpolystyrenenanoparticletemplatedopticalfiberplatformforinvivosurfaceenhancedramanspectroscopy |