White light diffuse optical spectroscopy for therapy monitoring
Since its rediscovery in 1973, Photodynamic Therapy (PDT) has emerged to be one of the novel cancer treatment modalities. In its very essence, it exploits light-activated drugs or better known as photosensitisers, and laser light to induce selective cytotoxicity. The effect of photosensitiser concen...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2011
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| Online Access: | http://hdl.handle.net/10356/45666 |
| _version_ | 1824455452720627712 |
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| author | Gunawan, Stephen Nathaniel. |
| author2 | Lee Kijoon |
| author_facet | Lee Kijoon Gunawan, Stephen Nathaniel. |
| author_sort | Gunawan, Stephen Nathaniel. |
| collection | NTU |
| description | Since its rediscovery in 1973, Photodynamic Therapy (PDT) has emerged to be one of the novel cancer treatment modalities. In its very essence, it exploits light-activated drugs or better known as photosensitisers, and laser light to induce selective cytotoxicity. The effect of photosensitiser concentration, blood oxygenation level, and sufficient light on the site play a major role in PDT’s clinical success.[1] A non-invasive therapy monitoring method is simplified by the development of Diffuse Optical Spectroscopy (DOS), where several important chromophores such as oxygenated haemoglobin (HbO2), deoxygenated haemoglobin (Hb), and photosensitiser concentration can be monitored constantly to provide a preliminary overview on the therapy progress[2] for clinicians to chart the subsequent courses of action. |
| first_indexed | 2025-02-19T03:38:26Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/45666 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:38:26Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/456662023-03-03T15:40:54Z White light diffuse optical spectroscopy for therapy monitoring Gunawan, Stephen Nathaniel. Lee Kijoon School of Chemical and Biomedical Engineering DRNTU::Science::Chemistry::Biochemistry::Spectroscopy DRNTU::Science::Medicine::Optical instruments Since its rediscovery in 1973, Photodynamic Therapy (PDT) has emerged to be one of the novel cancer treatment modalities. In its very essence, it exploits light-activated drugs or better known as photosensitisers, and laser light to induce selective cytotoxicity. The effect of photosensitiser concentration, blood oxygenation level, and sufficient light on the site play a major role in PDT’s clinical success.[1] A non-invasive therapy monitoring method is simplified by the development of Diffuse Optical Spectroscopy (DOS), where several important chromophores such as oxygenated haemoglobin (HbO2), deoxygenated haemoglobin (Hb), and photosensitiser concentration can be monitored constantly to provide a preliminary overview on the therapy progress[2] for clinicians to chart the subsequent courses of action. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2011-06-16T01:48:47Z 2011-06-16T01:48:47Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45666 en Nanyang Technological University 63 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Biochemistry::Spectroscopy DRNTU::Science::Medicine::Optical instruments Gunawan, Stephen Nathaniel. White light diffuse optical spectroscopy for therapy monitoring |
| title | White light diffuse optical spectroscopy for therapy monitoring |
| title_full | White light diffuse optical spectroscopy for therapy monitoring |
| title_fullStr | White light diffuse optical spectroscopy for therapy monitoring |
| title_full_unstemmed | White light diffuse optical spectroscopy for therapy monitoring |
| title_short | White light diffuse optical spectroscopy for therapy monitoring |
| title_sort | white light diffuse optical spectroscopy for therapy monitoring |
| topic | DRNTU::Science::Chemistry::Biochemistry::Spectroscopy DRNTU::Science::Medicine::Optical instruments |
| url | http://hdl.handle.net/10356/45666 |
| work_keys_str_mv | AT gunawanstephennathaniel whitelightdiffuseopticalspectroscopyfortherapymonitoring |