Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
149 p.
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| Other Authors: | |
| Format: | Thesis |
| Published: |
2011
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| Online Access: | https://hdl.handle.net/10356/47445 |
| _version_ | 1826114510617837568 |
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| author | Wu, Bin |
| author2 | Curtis Alexander Davey |
| author_facet | Curtis Alexander Davey Wu, Bin |
| author_sort | Wu, Bin |
| collection | NTU |
| description | 149 p. |
| first_indexed | 2024-10-01T03:40:23Z |
| format | Thesis |
| id | ntu-10356/47445 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T03:40:23Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/474452023-02-28T18:35:15Z Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction Wu, Bin Curtis Alexander Davey School of Biological Sciences RNTU::Science::Biological sciences 149 p. The nucleosome is an essential structural and functional feature of eukaryotic chromatin, which allows for hierarchical genomic regulation. Not only are histones heavily involved in genomic events, nucleosomal DNA is found to possess structural characteristics important for genomic function as well. The discovery of chromatin site-selective compounds could allow targeting of specific genes, which coincide with weak points of cancer cells. DOCTOR OF PHILOSOPHY (SBS) 2011-12-27T08:17:56Z 2011-12-27T08:17:56Z 2009 2009 Thesis Wu, B. (2009). Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47445 10.32657/10356/47445 Nanyang Technological University application/pdf |
| spellingShingle | RNTU::Science::Biological sciences Wu, Bin Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction |
| title | Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction |
| title_full | Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction |
| title_fullStr | Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction |
| title_full_unstemmed | Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction |
| title_short | Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction |
| title_sort | structural dynamics and site selectivity investigations of platinum anticancer drug nucleosome interaction |
| topic | RNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/47445 |
| work_keys_str_mv | AT wubin structuraldynamicsandsiteselectivityinvestigationsofplatinumanticancerdrugnucleosomeinteraction |