Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals
Dendritic cells are the heterogeneous and versatile regulators of immune system. They possess an inherent plasticity allowing them to either prime and boost the immune responses or induce immunological tolerance. They are the most potent APCs, specialized to capture, process and present antigens to...
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| التنسيق: | أطروحة |
| اللغة: | English |
| منشور في: |
2011
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/10356/47574 |
| _version_ | 1826119219167625216 |
|---|---|
| author | Hanif, Javanmard Khameneh |
| author2 | James P. Tam |
| author_facet | James P. Tam Hanif, Javanmard Khameneh |
| author_sort | Hanif, Javanmard Khameneh |
| collection | NTU |
| description | Dendritic cells are the heterogeneous and versatile regulators of immune system. They possess an inherent plasticity allowing them to either prime and boost the immune responses or induce immunological tolerance. They are the most potent APCs, specialized to capture, process and present antigens to T cells. Increased knowledge about their development and function will give us more opportunities to influence the immune system to our benefit. On one hand boosting of immunity towards multitude of infectious agents as well as against cancers is of high priority while on the other hand dampening or tolerizing the specific immune responses is highly desirable in many autoimmune diseases, clinical transplantations and in gene therapy settings. The goal of this project was to engineer ‘tailor made’ DCs with either “highly tolerogenic” or “immunostimulatory” properties through genetic and cellular manipulations, which could be used as tools for cellular therapies. To do this, we exploit the recent findings that the forced expression of HOXB4 homeo domain containing protein fused to NUP98 (NUP98-HOXB4) in hematopietic stem cells and primitive progenitors increases their self-renewal capacity in culture. |
| first_indexed | 2024-10-01T04:56:35Z |
| format | Thesis |
| id | ntu-10356/47574 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:56:35Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/475742023-02-28T18:39:17Z Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals Hanif, Javanmard Khameneh James P. Tam Ruedl Christiane School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Immunology Dendritic cells are the heterogeneous and versatile regulators of immune system. They possess an inherent plasticity allowing them to either prime and boost the immune responses or induce immunological tolerance. They are the most potent APCs, specialized to capture, process and present antigens to T cells. Increased knowledge about their development and function will give us more opportunities to influence the immune system to our benefit. On one hand boosting of immunity towards multitude of infectious agents as well as against cancers is of high priority while on the other hand dampening or tolerizing the specific immune responses is highly desirable in many autoimmune diseases, clinical transplantations and in gene therapy settings. The goal of this project was to engineer ‘tailor made’ DCs with either “highly tolerogenic” or “immunostimulatory” properties through genetic and cellular manipulations, which could be used as tools for cellular therapies. To do this, we exploit the recent findings that the forced expression of HOXB4 homeo domain containing protein fused to NUP98 (NUP98-HOXB4) in hematopietic stem cells and primitive progenitors increases their self-renewal capacity in culture. DOCTOR OF PHILOSOPHY (SBS) 2011-08-02T03:39:05Z 2012-01-05T06:56:20Z 2011-08-02T03:39:05Z 2012-01-05T06:56:20Z 2011 2011 Thesis Hanif, J. K. (2011). Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47574 10.32657/10356/47574 en 168 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Immunology Hanif, Javanmard Khameneh Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| title | Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| title_full | Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| title_fullStr | Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| title_full_unstemmed | Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| title_short | Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| title_sort | enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals |
| topic | DRNTU::Science::Biological sciences::Microbiology::Immunology |
| url | https://hdl.handle.net/10356/47574 |
| work_keys_str_mv | AT hanifjavanmardkhameneh enhancementoftolerogenicorimmunostimulatorypotentialofdendriticcellsfortherapeuticgoals |