Towards the design of drugs against the dengue virus RNA dependent RNA polymerase : mechanistic studies of enzyme activities and substrate binding.

Towards the design of drugs against the dengue virus RNA dependent RNA polymerase : mechanistic studies of enzyme activities and substrate binding.

Dengue NS5 consists of 2 domains- methyltransferase and RNA-dependent RNA polymerase (RdRp), interspersed by a 9 amino acid linker. Currently, the full-length (FL) NS5 has not been structurally determined due to the flexibility of this linker, impeding drug discovery efforts. Here, FL NS5 with alani...

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Bibliographic Details
Main Author:	Koh, Jolene Hong Kiew.
Other Authors:	Julien Lescar
Format:	Final Year Project (FYP)
Language:	English
Published:	2012
Subjects:	DRNTU::Science
Online Access:	http://hdl.handle.net/10356/49269

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