Towards the design of drugs against the dengue virus RNA dependent RNA polymerase : mechanistic studies of enzyme activities and substrate binding.
Dengue NS5 consists of 2 domains- methyltransferase and RNA-dependent RNA polymerase (RdRp), interspersed by a 9 amino acid linker. Currently, the full-length (FL) NS5 has not been structurally determined due to the flexibility of this linker, impeding drug discovery efforts. Here, FL NS5 with alani...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2012
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| Online Access: | http://hdl.handle.net/10356/49269 |