Material characterization of ca-alginate hydrogel
Biopolymeric hydrogels have been utilized as a technique to provide three-dimensional structures and microenvironment for many cell types in-vitro and in-vivo. Ca-alginate hydrogels have the potential of being a biocompatible polymeric scaffold with structurally similarity to the extra-cellular matr...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2012
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| Online Access: | http://hdl.handle.net/10356/49825 |
| _version_ | 1811693405158244352 |
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| author | Nabilah Mashhur Ali |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Nabilah Mashhur Ali |
| author_sort | Nabilah Mashhur Ali |
| collection | NTU |
| description | Biopolymeric hydrogels have been utilized as a technique to provide three-dimensional structures and microenvironment for many cell types in-vitro and in-vivo. Ca-alginate hydrogels have the potential of being a biocompatible polymeric scaffold with structurally similarity to the extra-cellular matrix. Recently in our lab, we have shown that it is able to support proliferation of encapsulated hematopoietic stem cells in-vitro. To better understand and control the impact of biophysical cues provided by alginate hydrogels, we performed mechanical and structural characterization of Ca-alginate hydrogels in varying chemical compositions. In this study, the effects of alginate viscosity, calcium ions and alginate concentration on the mechanical properties, surface topography, and swelling abilities were investigated. |
| first_indexed | 2024-10-01T06:51:09Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/49825 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:51:09Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/498252023-03-03T15:38:17Z Material characterization of ca-alginate hydrogel Nabilah Mashhur Ali School of Chemical and Biomedical Engineering Centre of Biotechnology Mayasari Lim DRNTU::Engineering::Bioengineering DRNTU::Engineering::Chemical engineering::Biotechnology Biopolymeric hydrogels have been utilized as a technique to provide three-dimensional structures and microenvironment for many cell types in-vitro and in-vivo. Ca-alginate hydrogels have the potential of being a biocompatible polymeric scaffold with structurally similarity to the extra-cellular matrix. Recently in our lab, we have shown that it is able to support proliferation of encapsulated hematopoietic stem cells in-vitro. To better understand and control the impact of biophysical cues provided by alginate hydrogels, we performed mechanical and structural characterization of Ca-alginate hydrogels in varying chemical compositions. In this study, the effects of alginate viscosity, calcium ions and alginate concentration on the mechanical properties, surface topography, and swelling abilities were investigated. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2012-05-24T08:53:55Z 2012-05-24T08:53:55Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/49825 en Nanyang Technological University 106 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering DRNTU::Engineering::Chemical engineering::Biotechnology Nabilah Mashhur Ali Material characterization of ca-alginate hydrogel |
| title | Material characterization of ca-alginate hydrogel |
| title_full | Material characterization of ca-alginate hydrogel |
| title_fullStr | Material characterization of ca-alginate hydrogel |
| title_full_unstemmed | Material characterization of ca-alginate hydrogel |
| title_short | Material characterization of ca-alginate hydrogel |
| title_sort | material characterization of ca alginate hydrogel |
| topic | DRNTU::Engineering::Bioengineering DRNTU::Engineering::Chemical engineering::Biotechnology |
| url | http://hdl.handle.net/10356/49825 |
| work_keys_str_mv | AT nabilahmashhurali materialcharacterizationofcaalginatehydrogel |