Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol
Currently, drug discovery and development is extremely expensive and time consuming, which results in low rates of new drugs reaching the market. One solution to alleviating this problem is to gain a better understanding of existing drug-cell interactions that will provide valuable insights into dru...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | https://hdl.handle.net/10356/50476 |
| _version_ | 1824453487099904000 |
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| author | Wang, Mingxuan |
| author2 | Chen Wei Ning, William |
| author_facet | Chen Wei Ning, William Wang, Mingxuan |
| author_sort | Wang, Mingxuan |
| collection | NTU |
| description | Currently, drug discovery and development is extremely expensive and time consuming, which results in low rates of new drugs reaching the market. One solution to alleviating this problem is to gain a better understanding of existing drug-cell interactions that will provide valuable insights into drug redeployment and new drug design. Protein and metabolite concentrations represent sensitive markers of cellular responses to drug treatment. Consequently, developing robust cell line-based proteomics and metabolomics platforms will greatly facilitate understanding of drug-cell interactions. |
| first_indexed | 2025-02-19T03:07:12Z |
| format | Thesis |
| id | ntu-10356/50476 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:07:12Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/504762020-11-06T00:06:00Z Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol Wang, Mingxuan Chen Wei Ning, William Ching Chi Bun School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biochemical engineering Currently, drug discovery and development is extremely expensive and time consuming, which results in low rates of new drugs reaching the market. One solution to alleviating this problem is to gain a better understanding of existing drug-cell interactions that will provide valuable insights into drug redeployment and new drug design. Protein and metabolite concentrations represent sensitive markers of cellular responses to drug treatment. Consequently, developing robust cell line-based proteomics and metabolomics platforms will greatly facilitate understanding of drug-cell interactions. DOCTOR OF PHILOSOPHY (SCBE) 2012-06-06T02:11:19Z 2012-06-06T02:11:19Z 2012 2012 Thesis Wang, M. X. (2012). Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/50476 10.32657/10356/50476 en 172 p. application/msword |
| spellingShingle | DRNTU::Engineering::Chemical engineering::Biochemical engineering Wang, Mingxuan Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol |
| title | Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol |
| title_full | Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol |
| title_fullStr | Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol |
| title_full_unstemmed | Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol |
| title_short | Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol |
| title_sort | proteomics and metabolomics analysis of cellular responses to β blocker carvedilol |
| topic | DRNTU::Engineering::Chemical engineering::Biochemical engineering |
| url | https://hdl.handle.net/10356/50476 |
| work_keys_str_mv | AT wangmingxuan proteomicsandmetabolomicsanalysisofcellularresponsestobblockercarvedilol |