Drug release mechanisms from bioerodible polymers for stent application
The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, cryst...
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| Format: | Thesis |
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2008
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| Online Access: | https://hdl.handle.net/10356/5048 |
| _version_ | 1824453119300337664 |
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| author | Alexis, Frank |
| author2 | Subbu S. Venkatraman |
| author_facet | Subbu S. Venkatraman Alexis, Frank |
| author_sort | Alexis, Frank |
| collection | NTU |
| description | The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine. |
| first_indexed | 2024-10-01T07:55:19Z |
| format | Thesis |
| id | ntu-10356/5048 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T07:55:19Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/50482023-03-04T16:46:56Z Drug release mechanisms from bioerodible polymers for stent application Alexis, Frank Subbu S. Venkatraman School of Materials Science & Engineering Freddy Boey DRNTU::Engineering::Materials::Biomaterials The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine. DOCTOR OF PHILOSOPHY (SME) 2008-09-17T10:18:24Z 2008-09-17T10:18:24Z 2005 2005 Thesis Alexis, F. (2005). Drug release mechanisms from bioerodible polymers for stent application. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/5048 10.32657/10356/5048 Nanyang Technological University 245 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Biomaterials Alexis, Frank Drug release mechanisms from bioerodible polymers for stent application |
| title | Drug release mechanisms from bioerodible polymers for stent application |
| title_full | Drug release mechanisms from bioerodible polymers for stent application |
| title_fullStr | Drug release mechanisms from bioerodible polymers for stent application |
| title_full_unstemmed | Drug release mechanisms from bioerodible polymers for stent application |
| title_short | Drug release mechanisms from bioerodible polymers for stent application |
| title_sort | drug release mechanisms from bioerodible polymers for stent application |
| topic | DRNTU::Engineering::Materials::Biomaterials |
| url | https://hdl.handle.net/10356/5048 |
| work_keys_str_mv | AT alexisfrank drugreleasemechanismsfrombioerodiblepolymersforstentapplication |