In silico folding and aggregation study of human amylin, an amyloidosis protein
Abnormal self-assembly of proteins converting their native conformations into β-sheet rich fibrillar structures is the hallmark of several so called "misfolding diseases" including Type 2 Diabetes Mellitus (T2DM), Alzheimer's and Parkinson's diseases, etc. Human islet amyloid pol...
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Format: | Thesis |
Language: | English |
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2012
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Online Access: | https://hdl.handle.net/10356/50957 |
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author | Jiang, Ping |
author2 | Mu Yuguang |
author_facet | Mu Yuguang Jiang, Ping |
author_sort | Jiang, Ping |
collection | NTU |
description | Abnormal self-assembly of proteins converting their native conformations into β-sheet rich fibrillar structures is the hallmark of several so called "misfolding diseases" including Type 2 Diabetes Mellitus (T2DM), Alzheimer's and Parkinson's diseases, etc. Human islet amyloid polypeptide (hlAPP or amylin) is the major component of amyloid deposits found in the pancreas of 90% T2DM patients. Although extensive studies have been performed in the recent decades, detailed information about hIAPP aggregation and the related pathology remains missing. |
first_indexed | 2024-10-01T03:23:55Z |
format | Thesis |
id | ntu-10356/50957 |
institution | Nanyang Technological University |
language | English |
last_indexed | 2024-10-01T03:23:55Z |
publishDate | 2012 |
record_format | dspace |
spelling | ntu-10356/509572023-02-28T18:34:19Z In silico folding and aggregation study of human amylin, an amyloidosis protein Jiang, Ping Mu Yuguang School of Biological Sciences DRNTU::Science::Biological sciences Abnormal self-assembly of proteins converting their native conformations into β-sheet rich fibrillar structures is the hallmark of several so called "misfolding diseases" including Type 2 Diabetes Mellitus (T2DM), Alzheimer's and Parkinson's diseases, etc. Human islet amyloid polypeptide (hlAPP or amylin) is the major component of amyloid deposits found in the pancreas of 90% T2DM patients. Although extensive studies have been performed in the recent decades, detailed information about hIAPP aggregation and the related pathology remains missing. DOCTOR OF PHILOSOPHY (SBS) 2012-12-26T06:44:26Z 2012-12-26T06:44:26Z 2011 2011 Thesis Jiang, P. (2011). In silico folding and aggregation study of human amylin, an amyloidosis protein. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/50957 10.32657/10356/50957 en 142 p. application/pdf |
spellingShingle | DRNTU::Science::Biological sciences Jiang, Ping In silico folding and aggregation study of human amylin, an amyloidosis protein |
title | In silico folding and aggregation study of human amylin, an amyloidosis protein |
title_full | In silico folding and aggregation study of human amylin, an amyloidosis protein |
title_fullStr | In silico folding and aggregation study of human amylin, an amyloidosis protein |
title_full_unstemmed | In silico folding and aggregation study of human amylin, an amyloidosis protein |
title_short | In silico folding and aggregation study of human amylin, an amyloidosis protein |
title_sort | in silico folding and aggregation study of human amylin an amyloidosis protein |
topic | DRNTU::Science::Biological sciences |
url | https://hdl.handle.net/10356/50957 |
work_keys_str_mv | AT jiangping insilicofoldingandaggregationstudyofhumanamylinanamyloidosisprotein |