Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment
Synthetic bioabsorbable polymers have been increasingly investigated as an alternative material for cardiovascular applications, attributed to their bioabsorbable and mechanical properties. However endothelialization on these bioabsorbable polymers appears difficult due to their poor cell a...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | http://hdl.handle.net/10356/51131 |
| _version_ | 1811683423105843200 |
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| author | Chia, Ngeow Khing. |
| author2 | Subramanian Venkatraman |
| author_facet | Subramanian Venkatraman Chia, Ngeow Khing. |
| author_sort | Chia, Ngeow Khing. |
| collection | NTU |
| description | Synthetic bioabsorbable polymers have been increasingly investigated as an alternative
material for cardiovascular applications, attributed to their bioabsorbable and
mechanical properties. However endothelialization on these bioabsorbable polymers
appears difficult due to their poor cell affinity and their surface roughness. This
research project seeks to study how two different surface modification techniques,
namely electron beam irradiation (ebeam) with sodium hydroxide (NaOH) treatment
and electron beam writing (EBW), have an effect on endothelial cell-surface
interaction and subsequent cell growth. The substrate material candidates chosen in
this study are poly(lactic-co-glycolic acid) (PLGA) co-polymer and poly(L-lactic acid)
(PLLA) polymer, because of their prevalent use as blood contacting devices in
cardiovascular applications.
In this work, randomized pattern obtained using electron beam irradiation with sodium
hydroxide treatment (NaOH), was compared against a nano-dimensional groove
pattern created by electron beam writing (EBW) for their influences on endothelial cell
proliferation and alignment on its films. |
| first_indexed | 2024-10-01T04:12:30Z |
| format | Thesis |
| id | ntu-10356/51131 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:12:30Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/511312023-03-04T16:34:16Z Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment Chia, Ngeow Khing. Subramanian Venkatraman School of Materials Science & Engineering DRNTU::Engineering::Materials::Nanostructured materials Synthetic bioabsorbable polymers have been increasingly investigated as an alternative material for cardiovascular applications, attributed to their bioabsorbable and mechanical properties. However endothelialization on these bioabsorbable polymers appears difficult due to their poor cell affinity and their surface roughness. This research project seeks to study how two different surface modification techniques, namely electron beam irradiation (ebeam) with sodium hydroxide (NaOH) treatment and electron beam writing (EBW), have an effect on endothelial cell-surface interaction and subsequent cell growth. The substrate material candidates chosen in this study are poly(lactic-co-glycolic acid) (PLGA) co-polymer and poly(L-lactic acid) (PLLA) polymer, because of their prevalent use as blood contacting devices in cardiovascular applications. In this work, randomized pattern obtained using electron beam irradiation with sodium hydroxide treatment (NaOH), was compared against a nano-dimensional groove pattern created by electron beam writing (EBW) for their influences on endothelial cell proliferation and alignment on its films. Doctor of Philosophy (MSE) 2013-02-05T03:58:35Z 2013-02-05T03:58:35Z 2013 2013 Thesis http://hdl.handle.net/10356/51131 en 192 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Nanostructured materials Chia, Ngeow Khing. Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| title | Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| title_full | Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| title_fullStr | Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| title_full_unstemmed | Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| title_short | Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| title_sort | study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment |
| topic | DRNTU::Engineering::Materials::Nanostructured materials |
| url | http://hdl.handle.net/10356/51131 |
| work_keys_str_mv | AT chiangeowkhing studyoftheeffectsofnanostructuringofpolymersurfacesoncellularproliferationandalignment |