Characterization of hippocampal CA1 place cells.
In 1971, O’Keefe & Dostrovsky discovered the highly selective firings of hippocampal principal cells when rats were in specific regions within an environment and prompted research on hippocampus role in spatial processing. In this study, rats were pre-trained in a square box prior to surgical im...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2013
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| Online Access: | http://hdl.handle.net/10356/52330 |
| _version_ | 1824453532124708864 |
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| author | Lau, Hwee Hui. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Lau, Hwee Hui. |
| author_sort | Lau, Hwee Hui. |
| collection | NTU |
| description | In 1971, O’Keefe & Dostrovsky discovered the highly selective firings of hippocampal principal cells when rats were in specific regions within an environment and prompted research on hippocampus role in spatial processing. In this study, rats were pre-trained in a square box prior to surgical implantation of microdrives into the brain for extracellular recording in the hippocampal CA1 pyramidal layer. A total of 9 recorded neurons displayed place cell properties. These neurons possessed unique place fields which were stable across sessions within the same environment, and discharged of action potential by a neuron is highly associated to the position the rat was in. Remapping of place fields were observed when rats were introduced into a novel environment. Results show that the physiologically identified neuron can have 1 or more place fields. Most of the neurons had stable firing across sessions recorded in both familiar and novel environments, while some showing selective discharged of spikes in either one of the environments tested. The data recorded had provided spatial-temporal pattern for study of neuronal activities of physiologically identified place cells residing in the hippocampal CA1 pyramidal layer. |
| first_indexed | 2025-02-19T03:07:55Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/52330 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:07:55Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/523302023-02-28T18:03:57Z Characterization of hippocampal CA1 place cells. Lau, Hwee Hui. School of Biological Sciences Ayumu Tashiro DRNTU::Science In 1971, O’Keefe & Dostrovsky discovered the highly selective firings of hippocampal principal cells when rats were in specific regions within an environment and prompted research on hippocampus role in spatial processing. In this study, rats were pre-trained in a square box prior to surgical implantation of microdrives into the brain for extracellular recording in the hippocampal CA1 pyramidal layer. A total of 9 recorded neurons displayed place cell properties. These neurons possessed unique place fields which were stable across sessions within the same environment, and discharged of action potential by a neuron is highly associated to the position the rat was in. Remapping of place fields were observed when rats were introduced into a novel environment. Results show that the physiologically identified neuron can have 1 or more place fields. Most of the neurons had stable firing across sessions recorded in both familiar and novel environments, while some showing selective discharged of spikes in either one of the environments tested. The data recorded had provided spatial-temporal pattern for study of neuronal activities of physiologically identified place cells residing in the hippocampal CA1 pyramidal layer. Bachelor of Science in Biological Sciences 2013-05-06T03:13:17Z 2013-05-06T03:13:17Z 2013 2013 Final Year Project (FYP) http://hdl.handle.net/10356/52330 en Nanyang Technological University 31 p. application/pdf |
| spellingShingle | DRNTU::Science Lau, Hwee Hui. Characterization of hippocampal CA1 place cells. |
| title | Characterization of hippocampal CA1 place cells. |
| title_full | Characterization of hippocampal CA1 place cells. |
| title_fullStr | Characterization of hippocampal CA1 place cells. |
| title_full_unstemmed | Characterization of hippocampal CA1 place cells. |
| title_short | Characterization of hippocampal CA1 place cells. |
| title_sort | characterization of hippocampal ca1 place cells |
| topic | DRNTU::Science |
| url | http://hdl.handle.net/10356/52330 |
| work_keys_str_mv | AT lauhweehui characterizationofhippocampalca1placecells |