The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome.
Transforming growth factor-beta/SMAD3 signaling has been implicated in various metabolic processes. However, the systemic effects of SMAD3 deficiency on adiposity and insulin resistance remain obscure. We found that SMAD3-knockout mice exhibited diminished adiposity with improved glucose tolerance a...
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| Materialtyp: | Lärdomsprov |
| Språk: | English |
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2013
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| Länkar: | http://hdl.handle.net/10356/52658 |
| _version_ | 1826118691571367936 |
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| author | Tan, Chek Kun. |
| author2 | Tan Nguan Soon |
| author_facet | Tan Nguan Soon Tan, Chek Kun. |
| author_sort | Tan, Chek Kun. |
| collection | NTU |
| description | Transforming growth factor-beta/SMAD3 signaling has been implicated in various metabolic processes. However, the systemic effects of SMAD3 deficiency on adiposity and insulin resistance remain obscure. We found that SMAD3-knockout mice exhibited diminished adiposity with improved glucose tolerance and insulin sensitivity and were resistant against the development of obesity and type 2 diabetes upon a high-fat diet
challenge, suggesting that SMAD3 is a potential target for the treatment of obesity and its associated disorders. Moreover, recent studies reveal that patients carrying SMAD3 mutations developed a syndromic form of aortic aneurysms. Yet, the underlying mechanism leading to the pathogenesis of aortic aneurysms in these patients still remain elusive. We found that SMAD3-knockout mice developed aortic aneurysms when infused with angiotensin II, ultimately died from aortic rupture. The mechanism of these severe abnormalities involves an aberrant upregulation of nitric oxide (NO) production mediated by inducible NO synthase and an activation of matrix metalloproteinase-9. |
| first_indexed | 2024-10-01T04:47:35Z |
| format | Thesis |
| id | ntu-10356/52658 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:47:35Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/526582023-02-28T18:38:44Z The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. Tan, Chek Kun. Tan Nguan Soon School of Biological Sciences DRNTU::Science Transforming growth factor-beta/SMAD3 signaling has been implicated in various metabolic processes. However, the systemic effects of SMAD3 deficiency on adiposity and insulin resistance remain obscure. We found that SMAD3-knockout mice exhibited diminished adiposity with improved glucose tolerance and insulin sensitivity and were resistant against the development of obesity and type 2 diabetes upon a high-fat diet challenge, suggesting that SMAD3 is a potential target for the treatment of obesity and its associated disorders. Moreover, recent studies reveal that patients carrying SMAD3 mutations developed a syndromic form of aortic aneurysms. Yet, the underlying mechanism leading to the pathogenesis of aortic aneurysms in these patients still remain elusive. We found that SMAD3-knockout mice developed aortic aneurysms when infused with angiotensin II, ultimately died from aortic rupture. The mechanism of these severe abnormalities involves an aberrant upregulation of nitric oxide (NO) production mediated by inducible NO synthase and an activation of matrix metalloproteinase-9. Doctor of Philosophy (SBS) 2013-05-21T09:04:15Z 2013-05-21T09:04:15Z 2013 2013 Thesis http://hdl.handle.net/10356/52658 en 254 p. application/pdf |
| spellingShingle | DRNTU::Science Tan, Chek Kun. The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. |
| title | The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. |
| title_full | The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. |
| title_fullStr | The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. |
| title_full_unstemmed | The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. |
| title_short | The role of transforming growth factor-beta/SMAD3 in the pathogenesis of metabolic syndrome. |
| title_sort | role of transforming growth factor beta smad3 in the pathogenesis of metabolic syndrome |
| topic | DRNTU::Science |
| url | http://hdl.handle.net/10356/52658 |
| work_keys_str_mv | AT tanchekkun theroleoftransforminggrowthfactorbetasmad3inthepathogenesisofmetabolicsyndrome AT tanchekkun roleoftransforminggrowthfactorbetasmad3inthepathogenesisofmetabolicsyndrome |