DNA and protein sequence analysis
The objective of this thesis is to improve the analysis of DNA and protein sequences. Sequence analysis is an important step in drug design to find the relationship among DNA sequences, protein sequences and their functions. The effectiveness of a drug is very much dependent on the correct associa...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Published: |
2008
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/5292 |
| _version_ | 1826129759075041280 |
|---|---|
| author | Yong, Kian Yan. |
| author2 | Shu, Jian Jun |
| author_facet | Shu, Jian Jun Yong, Kian Yan. |
| author_sort | Yong, Kian Yan. |
| collection | NTU |
| description | The objective of this thesis is to improve the analysis of DNA and protein sequences. Sequence analysis is an important step in drug design to find the relationship among DNA sequences, protein sequences and their functions. The effectiveness of a drug is very much dependent on the correct associations of the sequences to their functions. In this thesis, three novel methods have been developed to enhance the analysis of DNA and protein sequences. Two of the methods target the alignment and prediction of motif sites in DNA sequences. Their improvements are made by introducing joint and vector weight matrix scoring scheme. The third method targets the protein secondary structures, by using new classification indices. The new results show that the structures can be classified into more categories as compared with the existing methods, which hydrophobicity factor is solely considered as a classification index. |
| first_indexed | 2024-10-01T07:45:45Z |
| format | Thesis |
| id | ntu-10356/5292 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T07:45:45Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/52922023-03-11T17:36:10Z DNA and protein sequence analysis Yong, Kian Yan. Shu, Jian Jun School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering::Bio-mechatronics The objective of this thesis is to improve the analysis of DNA and protein sequences. Sequence analysis is an important step in drug design to find the relationship among DNA sequences, protein sequences and their functions. The effectiveness of a drug is very much dependent on the correct associations of the sequences to their functions. In this thesis, three novel methods have been developed to enhance the analysis of DNA and protein sequences. Two of the methods target the alignment and prediction of motif sites in DNA sequences. Their improvements are made by introducing joint and vector weight matrix scoring scheme. The third method targets the protein secondary structures, by using new classification indices. The new results show that the structures can be classified into more categories as compared with the existing methods, which hydrophobicity factor is solely considered as a classification index. Master of Engineering (MAE) 2008-09-17T10:47:10Z 2008-09-17T10:47:10Z 2007 2007 Thesis Yong, K. Y. (2007). DNA and protein sequence analysis. Master’s thesis, Nanyang Technological University, Singapore. http://hdl.handle.net/10356/5292 Nanyang Technological University application/pdf |
| spellingShingle | DRNTU::Engineering::Mechanical engineering::Bio-mechatronics Yong, Kian Yan. DNA and protein sequence analysis |
| title | DNA and protein sequence analysis |
| title_full | DNA and protein sequence analysis |
| title_fullStr | DNA and protein sequence analysis |
| title_full_unstemmed | DNA and protein sequence analysis |
| title_short | DNA and protein sequence analysis |
| title_sort | dna and protein sequence analysis |
| topic | DRNTU::Engineering::Mechanical engineering::Bio-mechatronics |
| url | http://hdl.handle.net/10356/5292 |
| work_keys_str_mv | AT yongkianyan dnaandproteinsequenceanalysis |