Microfluidic chip development for medical application
From inkjet printhead to micro-pneumatic systems, the field of microfluidics has been nothing short of a revolution. With advancements in the technology, micro-fluidics has also opened up a vast array of possibilities in biological applications. By utilizing the micro differences in the cell size...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10356/53442 |
| _version_ | 1826125763109191680 |
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| author | Chong, Zhi Wei. |
| author2 | Li King Ho Holden |
| author_facet | Li King Ho Holden Chong, Zhi Wei. |
| author_sort | Chong, Zhi Wei. |
| collection | NTU |
| description | From inkjet printhead to micro-pneumatic systems, the field of microfluidics has been nothing short of a revolution. With advancements in the technology, micro-fluidics has also opened up a vast array of possibilities in biological applications.
By utilizing the micro differences in the cell sizes and deformability of circulating tumor cells (CTCs) and normal blood cells, the complete operation from tumor cell capture to cell counting can now be done on a chip.
This Final Year Project focuses on the fluid flow simulation of the Microsieve Lab-Chip Device in order to provide more insights into the design of the micro device prior to manufacturing and laboratory testing via the use of ANSYS Workbench. The study on the flow aims to establish a relation between the entry flow rates of the fluid into the micro device and the formation of dead volumes within the fluid chamber, which may interfere with tumor cell collection. Various designs of the chamber will also be looked into to determine the effect that geometrical design differences may have on the formations of dead volumes within the chamber. |
| first_indexed | 2024-10-01T06:41:40Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/53442 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:41:40Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/534422023-03-04T19:30:55Z Microfluidic chip development for medical application Chong, Zhi Wei. Li King Ho Holden School of Mechanical and Aerospace Engineering A*STAR Singapore Institute of Manufacturing Technology Yoon Yong Jin DRNTU::Engineering::Manufacturing::Product design DRNTU::Engineering::Mechanical engineering::Fluid mechanics From inkjet printhead to micro-pneumatic systems, the field of microfluidics has been nothing short of a revolution. With advancements in the technology, micro-fluidics has also opened up a vast array of possibilities in biological applications. By utilizing the micro differences in the cell sizes and deformability of circulating tumor cells (CTCs) and normal blood cells, the complete operation from tumor cell capture to cell counting can now be done on a chip. This Final Year Project focuses on the fluid flow simulation of the Microsieve Lab-Chip Device in order to provide more insights into the design of the micro device prior to manufacturing and laboratory testing via the use of ANSYS Workbench. The study on the flow aims to establish a relation between the entry flow rates of the fluid into the micro device and the formation of dead volumes within the fluid chamber, which may interfere with tumor cell collection. Various designs of the chamber will also be looked into to determine the effect that geometrical design differences may have on the formations of dead volumes within the chamber. Bachelor of Engineering (Mechanical Engineering) 2013-06-03T07:38:24Z 2013-06-03T07:38:24Z 2013 2013 Final Year Project (FYP) http://hdl.handle.net/10356/53442 en Nanyang Technological University 76 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Manufacturing::Product design DRNTU::Engineering::Mechanical engineering::Fluid mechanics Chong, Zhi Wei. Microfluidic chip development for medical application |
| title | Microfluidic chip development for medical application |
| title_full | Microfluidic chip development for medical application |
| title_fullStr | Microfluidic chip development for medical application |
| title_full_unstemmed | Microfluidic chip development for medical application |
| title_short | Microfluidic chip development for medical application |
| title_sort | microfluidic chip development for medical application |
| topic | DRNTU::Engineering::Manufacturing::Product design DRNTU::Engineering::Mechanical engineering::Fluid mechanics |
| url | http://hdl.handle.net/10356/53442 |
| work_keys_str_mv | AT chongzhiwei microfluidicchipdevelopmentformedicalapplication |