A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/53489 |
| _version_ | 1826111406355775488 |
|---|---|
| author | Elavazhagan Murugan. |
| author2 | Liang Zhao-Xun |
| author_facet | Liang Zhao-Xun Elavazhagan Murugan. |
| author_sort | Elavazhagan Murugan. |
| collection | NTU |
| description | Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In this project, we examine the structures and functions of the domains of CalE8, to demarcate the domains of the the iterative PKS from the biosynthetic pathway of the 10-membered enediyne calicheamicin in Micromonospora echinospora spp. |
| first_indexed | 2024-10-01T02:50:11Z |
| format | Thesis |
| id | ntu-10356/53489 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:50:11Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/534892023-02-28T18:32:39Z A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. Elavazhagan Murugan. Liang Zhao-Xun School of Biological Sciences DRNTU::Science::Biological sciences Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In this project, we examine the structures and functions of the domains of CalE8, to demarcate the domains of the the iterative PKS from the biosynthetic pathway of the 10-membered enediyne calicheamicin in Micromonospora echinospora spp. DOCTOR OF PHILOSOPHY (SBS) 2013-06-04T04:44:44Z 2013-06-04T04:44:44Z 2012 2012 Thesis Elavazhagan Murugan. (2012). A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/53489 10.32657/10356/53489 en 181 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences Elavazhagan Murugan. A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. |
| title | A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. |
| title_full | A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. |
| title_fullStr | A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. |
| title_full_unstemmed | A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. |
| title_short | A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. |
| title_sort | study of the functional domains of the type i iterative polyketide synthase cale8 in calicheamicin biosynthesis |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/53489 |
| work_keys_str_mv | AT elavazhaganmurugan astudyofthefunctionaldomainsofthetypeiiterativepolyketidesynthasecale8incalicheamicinbiosynthesis AT elavazhaganmurugan studyofthefunctionaldomainsofthetypeiiterativepolyketidesynthasecale8incalicheamicinbiosynthesis |