Design and synthesis of cyclotides as druggable biologics.

Design and synthesis of cyclotides as druggable biologics.

Chronic pain is a universal health issue suffered by millions of patients. Current common treatments such as opiates and non-steroidal anti-inflammatory drugs remain problematic due to their side effects of different kinds and intensity. In this thesis, an alternative approach is established by bloc...

书目详细资料
主要作者:	Wong, Clarence Tsun Ting.
其他作者:	School of Biological Sciences
格式:	Thesis
语言:	English
出版:	2013
主题:	DRNTU::Science::Biological sciences
在线阅读:	http://hdl.handle.net/10356/53492

相似书籍

Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of Albumin-1 chain a and cyclotide domains in the Fabaceae family
由: Nguyen, Giang Kien Truc, et al.
出版: (2011)

Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
由: Wong, Clarence T. T., et al.
出版: (2013)

Pharmacological profiling of cyclotides from the medicinal herb clitoria ternatea for therapeutic applications
由: Nguyen Thi Kim Ngan
出版: (2015)

Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities
由: Nguyen, Giang Kien Truc, et al.
出版: (2013)

Chemical synthesis of circular proteins
由: Tam, James P., et al.
出版: (2013)

Adaptor regulation of LFA-1 signaling in T lymphocyte migration : potential druggable targets for immunotherapies?
由: Verma, Navin K., et al.
出版: (2015)

Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.
由: Koh, Samantha Qian Ping.
出版: (2011)

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket
由: Siau, Jia Wei, et al.
出版: (2019)

Proposing integrative learning of biology and data science : towards students' perception
由: Fu, Ting Ting
出版: (2018)

Systems biology analysis of plasmodium host parasite interactions.
由: Wong, Lu Yi.
出版: (2013)

Solid-Phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators
由: Hansen, Mette R., et al.
出版: (2014)

Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites
由: Kumar, Ammu Prasanna, et al.
出版: (2020)

Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
由: Xiaomin Cai, et al.
出版: (2024-06-01)

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer
由: Loo, Ser Yue, et al.
出版: (2022)

Design and synthesis of cysteine-rich peptides
由: Qiu, Yibo
出版: (2015)

Chemical synthesis of cyclotide from the medicinal plant clitoria ternatea
由: Wang, Yingqi
出版: (2013)

Structural biology of proteins involved in the replication of herpesviruses
由: Hew, Kelly Kai Li
出版: (2015)

Stem cell genome-to-systems biology
由: Chia, Na Yu, et al.
出版: (2013)

Discovery and characterization of novel peptide biologics in herbal medicine
由: Nguyen, Kien Truc Giang
出版: (2011)

FKBP family proteins : immunophilins with versatile biological functions
由: Kang, Cong Bao, et al.
出版: (2012)

Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study
由: Lei, Qiong, et al.
出版: (2014)

Study of vaults in skin biology and host defence - from in vitro to in vivo
由: Lian, Yilong
出版: (2019)

Cyclotides : a novel class of natural antibiotics
由: Ang, Koon Hwee
出版: (2013)

RNA biology in a test tube-an overview of in vitro systems/assays
由: Roca, Xavier, et al.
出版: (2013)

Dual characterization of biological cells by optofluidic microscope and resistive pulse sensor
由: Guo, Jinhong, et al.
出版: (2015)

Molecules of fatal attraction : biology of parasite-induced changes in host production
由: Yeow, William Wen Wang
出版: (2016)

New methodologies for the synthesis of proteins and construction of biomolecular assemblies.
由: Hou, Wen.
出版: (2013)

New methodologies for the synthesis of proteins and construction of biomolecular assemblies
由: Hou, Wen
出版: (2013)

Biological aging and social characteristics : gerontology, the Baltimore City Hospitals, and the National Institutes of Health
由: Park, Hyung Wook
出版: (2013)

Design and synthesis of gas-releasing antibiofilm polymers
由: Wang, Liping
出版: (2020)

Chemical and enzymatic methods for selective peptide and protein modification or synthesis
由: Tan, Xiaohong
出版: (2008)

Probing into the biological processes influenced by ESC factor and oncoprotein HMGA2 using iPSCs
由: Morshedi, Amir, et al.
出版: (2013)

Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein
由: Petersen, Mette T., et al.
出版: (2013)

Synthesis of (R)-Mellein by a partially reducing iterative polyketide synthase
由: Sun, Huihua, et al.
出版: (2013)

Genetic incorporation of unnatural amino acids for the synthesis of proteins with defined modifications
由: Bi, Xiaobao
出版: (2015)

Novel insights into the biological function of the high molecular weight PY235 rhoptry protein of plasmodium Yoelii
由: Jeya Kumar Ramalingam
出版: (2011)

Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma
由: Wang, Lei, et al.
出版: (2013)

Optimizing the synthesis of teixobactin and investigating the effects of cationicity of the macrocyclic pharmocophore on antibacterial activity
由: Ng, Belle Min Yee
出版: (2019)

Design and synthesis of novel nucleotides for enzymatic gene synthesis
由: Ee, Pin Koon
出版: (2021)

Characterization of novel neuroprotective ligands modulating molecular behavior of alpha synuclein in Parkinson's disease
由: Toh, Hui Ting
出版: (2014)