Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly
Human metapneumovirus was discovered in 2001. At the same time, it was also revealed that this virus had been circulating in the human population for at least 50 years. In the years that followed, an increasing number of research groups began to publish work on various aspects of HMPV. One of the ma...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/53649 |
| _version_ | 1824453346680897536 |
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| author | Loo, Liat Hui |
| author2 | Richard J. Sugrue |
| author_facet | Richard J. Sugrue Loo, Liat Hui |
| author_sort | Loo, Liat Hui |
| collection | NTU |
| description | Human metapneumovirus was discovered in 2001. At the same time, it was also revealed that this virus had been circulating in the human population for at least 50 years. In the years that followed, an increasing number of research groups began to publish work on various aspects of HMPV. One of the main concerns was that this virus was detected in a significant proportion of children below the age of 3 years and caused respiratory symptoms very similar to its nearest related human pathogen: human respiratory syncytial virus. Before this study, there had been no large scale study on the prevalence of HMPV in Singapore. There was also no existing data on the presence of HBoV, HCoV and HRV in hospitalized children in Singapore. We screened five hundred clincial nasopharyngeal samples and found that these four respiratory viruses are present in significant proportions. This discovery will hopefully lead to more research interest in the area of respiratory pathogens in children. |
| first_indexed | 2024-10-01T07:58:53Z |
| format | Thesis |
| id | ntu-10356/53649 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:58:53Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/536492023-02-28T18:48:36Z Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly Loo, Liat Hui Richard J. Sugrue School of Biological Sciences DRNTU::Science::Biological sciences Human metapneumovirus was discovered in 2001. At the same time, it was also revealed that this virus had been circulating in the human population for at least 50 years. In the years that followed, an increasing number of research groups began to publish work on various aspects of HMPV. One of the main concerns was that this virus was detected in a significant proportion of children below the age of 3 years and caused respiratory symptoms very similar to its nearest related human pathogen: human respiratory syncytial virus. Before this study, there had been no large scale study on the prevalence of HMPV in Singapore. There was also no existing data on the presence of HBoV, HCoV and HRV in hospitalized children in Singapore. We screened five hundred clincial nasopharyngeal samples and found that these four respiratory viruses are present in significant proportions. This discovery will hopefully lead to more research interest in the area of respiratory pathogens in children. DOCTOR OF PHILOSOPHY (SBS) 2013-06-06T07:45:52Z 2013-06-06T07:45:52Z 2012 2012 Thesis Loo, L. H. (2012). Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/53649 10.32657/10356/53649 en 299 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences Loo, Liat Hui Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly |
| title | Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly |
| title_full | Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly |
| title_fullStr | Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly |
| title_full_unstemmed | Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly |
| title_short | Human metapneumovirus in Singapore : epidemiology, fusion-attachment protein interaction and virus-like particle assembly |
| title_sort | human metapneumovirus in singapore epidemiology fusion attachment protein interaction and virus like particle assembly |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/53649 |
| work_keys_str_mv | AT looliathui humanmetapneumovirusinsingaporeepidemiologyfusionattachmentproteininteractionandviruslikeparticleassembly |