Structural studies of the nucleosome, assembled with different histones, DNA fragments and HMGN proteins, and derivatized with ruthenium anticancer agents
The nucleosome forms the basic unit of chromatin in eukaryotic cells. This compact structure made of four histone proteins and DNA serves dual interrelated functions for storage and regulation of genomic activities. Nucleosome dynamics, histone variants, histone post-translational modification, nucl...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/53656 |