Age-related changes in functional hemispheric asymmetry : an fMRI study.
Global aging has increased the pace and significance to study age-related neural changes to better understand the aging process and prevent related diseases. Neuroimaging literature in aging has suggested cereberal symmetry, a well-established phenomenon, to be less prominent in the elderly in the p...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2013
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| Online Access: | http://hdl.handle.net/10356/53715 |
| _version_ | 1826120168774828032 |
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| author | Heng, Gladys Jiamin |
| author2 | School of Humanities and Social Sciences |
| author_facet | School of Humanities and Social Sciences Heng, Gladys Jiamin |
| author_sort | Heng, Gladys Jiamin |
| collection | NTU |
| description | Global aging has increased the pace and significance to study age-related neural changes to better understand the aging process and prevent related diseases. Neuroimaging literature in aging has suggested cereberal symmetry, a well-established phenomenon, to be less prominent in the elderly in the prefrontal cortex (Cabeza, 2002). This is known as the hemispheric asymmetry reduction in older adults (HAROLD). Although there is extensive literature on language and visuospatial processing, there seems to be a lack of research investigating the age-related changes that accompany these processes. This study aims to investigate age-related changes in functional hemispheric asymmetry by examining language processing, which is known to be left-lateralized, and visuospatial processing, which is known to be right-lateralized. Tasks utilizing homophone judgment and line orientation judgment were designed to elicit these processes respectively. Grey matter atrophy was accounted for by using the grey matter probability maps created from Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) as covariates in analyses and AveLI was used to provide a quantitative measurement of functional lateralization. Results showed that the homophone judgment task produced left-lateralization in frontal regions for both young and older adults. Right fronto-parietal activations were seen when line orientation was contrasted against homophone judgment in both groups. Although AveLI scores were not significantly different, older adults showed increased bilateral frontal activity for both tasks. Our data thus provide more support for the compensation-related utilization of neural circuits hypothesis (CRUNCH) rather than the HAROLD model. |
| first_indexed | 2024-10-01T05:12:05Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/53715 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:12:05Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/537152019-12-10T12:43:08Z Age-related changes in functional hemispheric asymmetry : an fMRI study. Heng, Gladys Jiamin School of Humanities and Social Sciences S.H. Annabel Chen DRNTU::Social sciences::Sociology Global aging has increased the pace and significance to study age-related neural changes to better understand the aging process and prevent related diseases. Neuroimaging literature in aging has suggested cereberal symmetry, a well-established phenomenon, to be less prominent in the elderly in the prefrontal cortex (Cabeza, 2002). This is known as the hemispheric asymmetry reduction in older adults (HAROLD). Although there is extensive literature on language and visuospatial processing, there seems to be a lack of research investigating the age-related changes that accompany these processes. This study aims to investigate age-related changes in functional hemispheric asymmetry by examining language processing, which is known to be left-lateralized, and visuospatial processing, which is known to be right-lateralized. Tasks utilizing homophone judgment and line orientation judgment were designed to elicit these processes respectively. Grey matter atrophy was accounted for by using the grey matter probability maps created from Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) as covariates in analyses and AveLI was used to provide a quantitative measurement of functional lateralization. Results showed that the homophone judgment task produced left-lateralization in frontal regions for both young and older adults. Right fronto-parietal activations were seen when line orientation was contrasted against homophone judgment in both groups. Although AveLI scores were not significantly different, older adults showed increased bilateral frontal activity for both tasks. Our data thus provide more support for the compensation-related utilization of neural circuits hypothesis (CRUNCH) rather than the HAROLD model. Bachelor of Arts 2013-06-07T02:03:54Z 2013-06-07T02:03:54Z 2013 2013 Final Year Project (FYP) http://hdl.handle.net/10356/53715 en Nanyang Technological University 63 p. application/pdf |
| spellingShingle | DRNTU::Social sciences::Sociology Heng, Gladys Jiamin Age-related changes in functional hemispheric asymmetry : an fMRI study. |
| title | Age-related changes in functional hemispheric asymmetry : an fMRI study. |
| title_full | Age-related changes in functional hemispheric asymmetry : an fMRI study. |
| title_fullStr | Age-related changes in functional hemispheric asymmetry : an fMRI study. |
| title_full_unstemmed | Age-related changes in functional hemispheric asymmetry : an fMRI study. |
| title_short | Age-related changes in functional hemispheric asymmetry : an fMRI study. |
| title_sort | age related changes in functional hemispheric asymmetry an fmri study |
| topic | DRNTU::Social sciences::Sociology |
| url | http://hdl.handle.net/10356/53715 |
| work_keys_str_mv | AT henggladysjiamin agerelatedchangesinfunctionalhemisphericasymmetryanfmristudy |