Redevelopment of polymeric encapsulants for delivery of chemical reactants
Sodium percarbonate was incorporated in the PCL microcapsules to achieve sustained release of oxygen, with the goal of providing a viable source of oxygen for the prolonging tissue survival in wound healing and organ regeneration. Encapsulation of water sensitive sodium percarbonate was achieved...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/53983 |
| _version_ | 1826111484748365824 |
|---|---|
| author | Yang, Tianyu |
| author2 | Chian Kerm Sin |
| author_facet | Chian Kerm Sin Yang, Tianyu |
| author_sort | Yang, Tianyu |
| collection | NTU |
| description | Sodium percarbonate was incorporated in the PCL microcapsules to achieve sustained release of oxygen, with the goal of providing a viable source of oxygen for the prolonging tissue survival in wound healing and organ regeneration.
Encapsulation of water sensitive sodium percarbonate was achieved using oil-in-oil emulsion technique. Polycaprolactone serves as the polymeric shell and polyethylene glycol acts as the surfactant.
Scanning electron microscopy revealed that most of the particles are clumped together without any specific shape. This is partly due to the semi-crystalline nature of PCL and its low rigidity. In addition, agglomeration occurred throughout all the formulations, thus increasing the effective particle size. The effects of agglomeration could have been magnified by the high shear stress introduced by the homogenizer and the use of PEG 10,000 as the binder. Agglomeration is controlled by a wide variety of factors and altering them could reduce the effects of agglomeration.
In vitro timed water immersion test revealed that among the formulations used, using 10 wt% of PEG yielded better results. The microcapsules lasted for a longer duration (1 hour) as compared to other formulations (30 mins).
It was proposed that the release of oxygen was caused by PEG dissolving in water, which creates channels in the polymeric shell for water to diffuse in to react with sodium percarbonate and release oxygen. Oxygen may have escaped through these channels or accumulated within the microcapsule until it ruptures due to excessive pressure. |
| first_indexed | 2024-10-01T02:51:29Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/53983 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:51:29Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/539832023-03-04T18:49:26Z Redevelopment of polymeric encapsulants for delivery of chemical reactants Yang, Tianyu Chian Kerm Sin School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering Sodium percarbonate was incorporated in the PCL microcapsules to achieve sustained release of oxygen, with the goal of providing a viable source of oxygen for the prolonging tissue survival in wound healing and organ regeneration. Encapsulation of water sensitive sodium percarbonate was achieved using oil-in-oil emulsion technique. Polycaprolactone serves as the polymeric shell and polyethylene glycol acts as the surfactant. Scanning electron microscopy revealed that most of the particles are clumped together without any specific shape. This is partly due to the semi-crystalline nature of PCL and its low rigidity. In addition, agglomeration occurred throughout all the formulations, thus increasing the effective particle size. The effects of agglomeration could have been magnified by the high shear stress introduced by the homogenizer and the use of PEG 10,000 as the binder. Agglomeration is controlled by a wide variety of factors and altering them could reduce the effects of agglomeration. In vitro timed water immersion test revealed that among the formulations used, using 10 wt% of PEG yielded better results. The microcapsules lasted for a longer duration (1 hour) as compared to other formulations (30 mins). It was proposed that the release of oxygen was caused by PEG dissolving in water, which creates channels in the polymeric shell for water to diffuse in to react with sodium percarbonate and release oxygen. Oxygen may have escaped through these channels or accumulated within the microcapsule until it ruptures due to excessive pressure. Bachelor of Engineering (Mechanical Engineering) 2013-06-11T03:32:55Z 2013-06-11T03:32:55Z 2013 2013 Final Year Project (FYP) http://hdl.handle.net/10356/53983 en Nanyang Technological University 43 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Yang, Tianyu Redevelopment of polymeric encapsulants for delivery of chemical reactants |
| title | Redevelopment of polymeric encapsulants for delivery of chemical reactants |
| title_full | Redevelopment of polymeric encapsulants for delivery of chemical reactants |
| title_fullStr | Redevelopment of polymeric encapsulants for delivery of chemical reactants |
| title_full_unstemmed | Redevelopment of polymeric encapsulants for delivery of chemical reactants |
| title_short | Redevelopment of polymeric encapsulants for delivery of chemical reactants |
| title_sort | redevelopment of polymeric encapsulants for delivery of chemical reactants |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | http://hdl.handle.net/10356/53983 |
| work_keys_str_mv | AT yangtianyu redevelopmentofpolymericencapsulantsfordeliveryofchemicalreactants |