Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells
In normal condition, the adherence of normal red blood cells (RBC) with endothelial cells (EC) is usually insignificant. However, such insignificant adhesion is magnified in several pathological conditions and the mechanisms of such adhesion have been poorly understood. The present study investigate...
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| Format: | Thesis |
| Sprog: | English |
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2013
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| Online adgang: | http://hdl.handle.net/10356/54362 |
| _version_ | 1826124045844742144 |
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| author | Zhang, Shipin |
| author2 | Song Hao |
| author_facet | Song Hao Zhang, Shipin |
| author_sort | Zhang, Shipin |
| collection | NTU |
| description | In normal condition, the adherence of normal red blood cells (RBC) with endothelial cells (EC) is usually insignificant. However, such insignificant adhesion is magnified in several pathological conditions and the mechanisms of such adhesion have been poorly understood. The present study investigated whether depletion mechanism mediate diabetic red blood cells adhesion to endothelial cells. The results showed that both 500kDa dextran and 70kDa dextran promote RBC adhesion with EC and the adhesion efficiency is elevated with the increase of the molecular weight of dextran. Hence, the present study reveals a novel mechanism of RBC-EC interaction in diabetes mellitus and provides new therapeutic approach to prevent vascular complications associated with RBC-EC interaction. |
| first_indexed | 2024-10-01T06:14:15Z |
| format | Thesis |
| id | ntu-10356/54362 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:14:15Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/543622023-03-03T16:03:56Z Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells Zhang, Shipin Song Hao School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering In normal condition, the adherence of normal red blood cells (RBC) with endothelial cells (EC) is usually insignificant. However, such insignificant adhesion is magnified in several pathological conditions and the mechanisms of such adhesion have been poorly understood. The present study investigated whether depletion mechanism mediate diabetic red blood cells adhesion to endothelial cells. The results showed that both 500kDa dextran and 70kDa dextran promote RBC adhesion with EC and the adhesion efficiency is elevated with the increase of the molecular weight of dextran. Hence, the present study reveals a novel mechanism of RBC-EC interaction in diabetes mellitus and provides new therapeutic approach to prevent vascular complications associated with RBC-EC interaction. Master of Science (Biomedical Engineering) 2013-06-19T06:50:35Z 2013-06-19T06:50:35Z 2013 2013 Thesis http://hdl.handle.net/10356/54362 en 52 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Zhang, Shipin Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| title | Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| title_full | Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| title_fullStr | Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| title_full_unstemmed | Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| title_short | Macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| title_sort | macromolecular depletion modulates the binding of diabetic erythrocytes to endothelial cells |
| topic | DRNTU::Engineering::Bioengineering |
| url | http://hdl.handle.net/10356/54362 |
| work_keys_str_mv | AT zhangshipin macromoleculardepletionmodulatesthebindingofdiabeticerythrocytestoendothelialcells |