Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation
During the past decades, transition metal-catalyzed chelation-assisted C–H bond functionalization has been developed as an efficient and regioselective synthetic strategy. While this chemistry has met with significant success with expensive second-row transition metals, catalysis with cheaper first-...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/55291 |
| _version_ | 1811677633415479296 |
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| author | Gao, Ke |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Gao, Ke |
| author_sort | Gao, Ke |
| collection | NTU |
| description | During the past decades, transition metal-catalyzed chelation-assisted C–H bond functionalization has been developed as an efficient and regioselective synthetic strategy. While this chemistry has met with significant success with expensive second-row transition metals, catalysis with cheaper first-row transition metals could lead to the development of cost-effective alternative catalysts as well as the discovery of new reactions.
This thesis describes the development of cobalt-based catalysts for chelation-assisted C–H bond functionalization reactions. A serials of C–C bond forming reactions, including alkenylation, alkylation, and arylation, have been achieved on aromatic substrates bearing pyridine or imine directing groups. The cobalt catalysts not only serve as mild and less expensive alternatives to noble metal catalysts for existing reactions, but also show unique reactivities and selectivities and thus enable transformations that were previously difficult to achieve. |
| first_indexed | 2024-10-01T02:40:28Z |
| format | Thesis |
| id | ntu-10356/55291 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:40:28Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/552912023-02-28T23:33:09Z Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation Gao, Ke School of Physical and Mathematical Sciences Naohiko Yoshikai DRNTU::Science::Chemistry During the past decades, transition metal-catalyzed chelation-assisted C–H bond functionalization has been developed as an efficient and regioselective synthetic strategy. While this chemistry has met with significant success with expensive second-row transition metals, catalysis with cheaper first-row transition metals could lead to the development of cost-effective alternative catalysts as well as the discovery of new reactions. This thesis describes the development of cobalt-based catalysts for chelation-assisted C–H bond functionalization reactions. A serials of C–C bond forming reactions, including alkenylation, alkylation, and arylation, have been achieved on aromatic substrates bearing pyridine or imine directing groups. The cobalt catalysts not only serve as mild and less expensive alternatives to noble metal catalysts for existing reactions, but also show unique reactivities and selectivities and thus enable transformations that were previously difficult to achieve. DOCTOR OF PHILOSOPHY (SPMS) 2014-01-28T03:36:40Z 2014-01-28T03:36:40Z 2013 2013 Thesis Gao, K. (2013). Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/55291 10.32657/10356/55291 en 244 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry Gao, Ke Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation |
| title | Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation |
| title_full | Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation |
| title_fullStr | Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation |
| title_full_unstemmed | Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation |
| title_short | Cobalt-catalyzed chelation-assisted C-C bond formation via C-H bond activation |
| title_sort | cobalt catalyzed chelation assisted c c bond formation via c h bond activation |
| topic | DRNTU::Science::Chemistry |
| url | https://hdl.handle.net/10356/55291 |
| work_keys_str_mv | AT gaoke cobaltcatalyzedchelationassistedccbondformationviachbondactivation |