The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation.
The Rho GTPases are a family of small GTP binding proteins belonging to the Ras superfamily and are known to be crucial in the regulation of a myriad of cellular events such as cell growth, cell movement and motility, transcription and cell cycle control. They also play an important role in the cont...
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| Formato: | Research Report |
| Lenguaje: | English |
| Publicado: |
2014
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| Acceso en línea: | http://hdl.handle.net/10356/55375 |
| _version_ | 1826109471521243136 |
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| author | Koh, Cheng Gee |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Koh, Cheng Gee |
| author_sort | Koh, Cheng Gee |
| collection | NTU |
| description | The Rho GTPases are a family of small GTP binding proteins belonging to the Ras superfamily and are known to be crucial in the regulation of a myriad of cellular events such as cell growth, cell movement and motility, transcription and cell cycle control. They also play an important role in the control of cell morphology, which is critically dependent on the regulation of the actin cytoskeleton. Although the effects of Rho GTPases on the modulation of the actin cytoskeleton are well documented, the dynamic behaviour of actin cytoskeleton which is also intimately connected with the cell cycle progression is less well studied. It is known that while interphase cells contain extensive cytoskeletal network, entry into mitosis is accompanied by the dissolution of this network resulting in the loss of attachment to the cell matrix and rounding up of the cells. The cytoskeletal network is rebuilt as cells re-enter interphase upon completion of mitosis. This dynamic integration of actin cytoskeleton regulation with cell cycle progression is not well understood at molecular level. This project aims to decipher the molecular mechanism, which links the control of the actin cytokseleton and the regulation of cell cycle progression. |
| first_indexed | 2024-10-01T02:18:24Z |
| format | Research Report |
| id | ntu-10356/55375 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:18:24Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/553752023-02-28T17:58:08Z The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. Koh, Cheng Gee School of Biological Sciences DRNTU::Science::Biological sciences The Rho GTPases are a family of small GTP binding proteins belonging to the Ras superfamily and are known to be crucial in the regulation of a myriad of cellular events such as cell growth, cell movement and motility, transcription and cell cycle control. They also play an important role in the control of cell morphology, which is critically dependent on the regulation of the actin cytoskeleton. Although the effects of Rho GTPases on the modulation of the actin cytoskeleton are well documented, the dynamic behaviour of actin cytoskeleton which is also intimately connected with the cell cycle progression is less well studied. It is known that while interphase cells contain extensive cytoskeletal network, entry into mitosis is accompanied by the dissolution of this network resulting in the loss of attachment to the cell matrix and rounding up of the cells. The cytoskeletal network is rebuilt as cells re-enter interphase upon completion of mitosis. This dynamic integration of actin cytoskeleton regulation with cell cycle progression is not well understood at molecular level. This project aims to decipher the molecular mechanism, which links the control of the actin cytokseleton and the regulation of cell cycle progression. 2014-02-25T07:35:17Z 2014-02-25T07:35:17Z 2011 2011 Research Report http://hdl.handle.net/10356/55375 en 51 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences Koh, Cheng Gee The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. |
| title | The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. |
| title_full | The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. |
| title_fullStr | The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. |
| title_full_unstemmed | The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. |
| title_short | The regulation of actin cytoskeleton in mouse embryonic stem cells during self-renewal and differentiation. |
| title_sort | regulation of actin cytoskeleton in mouse embryonic stem cells during self renewal and differentiation |
| topic | DRNTU::Science::Biological sciences |
| url | http://hdl.handle.net/10356/55375 |
| work_keys_str_mv | AT kohchenggee theregulationofactincytoskeletoninmouseembryonicstemcellsduringselfrenewalanddifferentiation AT kohchenggee regulationofactincytoskeletoninmouseembryonicstemcellsduringselfrenewalanddifferentiation |