Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules.
In Part 1, we would like to introduce a new protocol for the synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins using Pd(PhCN)2Cl2 (10 mol%) as a catalyst and K2CO3 (0.5 equiv) in dioxane. Both vinyl-pyridine and enamides were able to afford the corresponding products in mo...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | http://hdl.handle.net/10356/55385 |
| _version_ | 1811687051889737728 |
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| author | Wang, Wee Jian. |
| author2 | Loh Teck Peng |
| author_facet | Loh Teck Peng Wang, Wee Jian. |
| author_sort | Wang, Wee Jian. |
| collection | NTU |
| description | In Part 1, we would like to introduce a new protocol for the synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins using Pd(PhCN)2Cl2 (10 mol%) as a catalyst and K2CO3 (0.5 equiv) in dioxane. Both vinyl-pyridine and enamides were able to afford the corresponding products in moderate to good yields using this novel method. Substituents are well tolerated in this reaction furnishing products which are potential useful intermediate that can be used for further transformation. Next in Part 2, we would like to present results from explorative studies on the synthesis of triene via C‒H functionalization and the transformation of trienes to complex molecules. |
| first_indexed | 2024-10-01T05:10:10Z |
| format | Thesis |
| id | ntu-10356/55385 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:10:10Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/553852023-02-28T23:44:35Z Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. Wang, Wee Jian. Loh Teck Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis In Part 1, we would like to introduce a new protocol for the synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins using Pd(PhCN)2Cl2 (10 mol%) as a catalyst and K2CO3 (0.5 equiv) in dioxane. Both vinyl-pyridine and enamides were able to afford the corresponding products in moderate to good yields using this novel method. Substituents are well tolerated in this reaction furnishing products which are potential useful intermediate that can be used for further transformation. Next in Part 2, we would like to present results from explorative studies on the synthesis of triene via C‒H functionalization and the transformation of trienes to complex molecules. Master of Science 2014-02-26T01:48:57Z 2014-02-26T01:48:57Z 2013 2013 Thesis http://hdl.handle.net/10356/55385 en 70 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis Wang, Wee Jian. Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. |
| title | Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. |
| title_full | Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. |
| title_fullStr | Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. |
| title_full_unstemmed | Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. |
| title_short | Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. |
| title_sort | part 1 synthesis of vinyl sulfones via palladium catalyzed sulfonylation of olefins part 2 trienes synthesis via c h functionalization and as precursors to complex molecules |
| topic | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis |
| url | http://hdl.handle.net/10356/55385 |
| work_keys_str_mv | AT wangweejian part1synthesisofvinylsulfonesviapalladiumcatalyzedsulfonylationofolefinspart2trienessynthesisviachfunctionalizationandasprecursorstocomplexmolecules |