Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
193 p.
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Published: |
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/57411 |
| _version_ | 1824453718394798080 |
|---|---|
| author | Zhang, Zhengwen |
| author2 | Bjoern Holger Neu |
| author_facet | Bjoern Holger Neu Zhang, Zhengwen |
| author_sort | Zhang, Zhengwen |
| collection | NTU |
| description | 193 p. |
| first_indexed | 2025-02-19T03:10:52Z |
| format | Thesis |
| id | ntu-10356/57411 |
| institution | Nanyang Technological University |
| last_indexed | 2025-02-19T03:10:52Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/574112023-03-03T16:07:15Z Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. Zhang, Zhengwen Bjoern Holger Neu School of Chemical and Biomedical Engineering DRNTU::Science::Biological sciences::Molecular biology 193 p. Multiple specific and non-specific forces govern cell-cell interaction. One weak non-specific interaction induced by macromolecular depletion at the cell surface has recently been suggested to play a key role in reversible RBC aggregation and in promoting RBC adhesion to other surfaces. A depletion layer develops near a surface in contact with a polymer solution if the loss of configurational entropy of the polymer is not balanced by an adsorption energy. Within this layer, the polymer concentration is lower than in the bulk phase. If a particle or cell approaches another particle in a solution containing a depleted polymer, then the difference of solvent chemical potential between the polymer-poor depletion zone and the bulk phase results in solvent displacement into the bulk phase and hence depletion interaction. Due to this interaction, an attractive force develops that tends to minimize the polymer-reduced space between particles and cells, thus resulting in flocculation or aggregation. Doctor of Philosophy (SCBE) 2014-04-07T10:29:18Z 2014-04-07T10:29:18Z 2011 2011 Thesis http://hdl.handle.net/10356/57411 Nanyang Technological University application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Molecular biology Zhang, Zhengwen Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. |
| title | Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. |
| title_full | Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. |
| title_fullStr | Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. |
| title_full_unstemmed | Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. |
| title_short | Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. |
| title_sort | red blood cell adhesion to artificial surfaces in the presence of non adsorbing macromolecules |
| topic | DRNTU::Science::Biological sciences::Molecular biology |
| url | http://hdl.handle.net/10356/57411 |
| work_keys_str_mv | AT zhangzhengwen redbloodcelladhesiontoartificialsurfacesinthepresenceofnonadsorbingmacromolecules |