Engineering polymeric and hybrid microparticles as novel controlled release systems
Controlled drug release systems offer improved efficiency, reduced side-effects, and enhanced patient compliance over conventional drugs. While poly (lactic-co-glycolic) acid (PLGA) remains a popular candidate for controlled release of drugs and biomolecules, this single material formulation possess...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/60829 |
| _version_ | 1826129822189879296 |
|---|---|
| author | Luo, Daniel Chin Shiuan |
| author2 | Cheong Yuen Yee, Wendy |
| author_facet | Cheong Yuen Yee, Wendy Luo, Daniel Chin Shiuan |
| author_sort | Luo, Daniel Chin Shiuan |
| collection | NTU |
| description | Controlled drug release systems offer improved efficiency, reduced side-effects, and enhanced patient compliance over conventional drugs. While poly (lactic-co-glycolic) acid (PLGA) remains a popular candidate for controlled release of drugs and biomolecules, this single material formulation possesses low encapsulation efficiency and high initial burst release in release profile. In view of this, numerous efforts have been spent to design a variety of particle types encompassing different sizes, composites, and morphologies to improve drug delivery. However, none of the systems were able to produce particles with both improved loading efficiency and controlled release profile. In this study, incorporation of hydrogel core (alginate) in PLGA microparticles demonstrated higher loading efficiency and low release profile. Furthermore, combination of fabrication techniques enabled development of a wider range of controlled release formulations. Thereafter, in vitro experiments demonstrated a variety of loading capabilities for polymer-hydrogel composite microparticles in mesenchymal stem cells (MSCs). Hence, novel combinations of polymeric and hybrid particles served to overcome low encapsulation efficiency and provide tailored drug release profiles. |
| first_indexed | 2024-10-01T07:46:27Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/60829 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:46:27Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/608292023-03-03T15:39:45Z Engineering polymeric and hybrid microparticles as novel controlled release systems Luo, Daniel Chin Shiuan Cheong Yuen Yee, Wendy School of Chemical and Biomedical Engineering Asst Prof Xu Chenjie DRNTU::Engineering::Bioengineering Controlled drug release systems offer improved efficiency, reduced side-effects, and enhanced patient compliance over conventional drugs. While poly (lactic-co-glycolic) acid (PLGA) remains a popular candidate for controlled release of drugs and biomolecules, this single material formulation possesses low encapsulation efficiency and high initial burst release in release profile. In view of this, numerous efforts have been spent to design a variety of particle types encompassing different sizes, composites, and morphologies to improve drug delivery. However, none of the systems were able to produce particles with both improved loading efficiency and controlled release profile. In this study, incorporation of hydrogel core (alginate) in PLGA microparticles demonstrated higher loading efficiency and low release profile. Furthermore, combination of fabrication techniques enabled development of a wider range of controlled release formulations. Thereafter, in vitro experiments demonstrated a variety of loading capabilities for polymer-hydrogel composite microparticles in mesenchymal stem cells (MSCs). Hence, novel combinations of polymeric and hybrid particles served to overcome low encapsulation efficiency and provide tailored drug release profiles. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2014-06-02T02:32:54Z 2014-06-02T02:32:54Z 2014 2014 Final Year Project (FYP) http://hdl.handle.net/10356/60829 en Nanyang Technological University 51 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Luo, Daniel Chin Shiuan Engineering polymeric and hybrid microparticles as novel controlled release systems |
| title | Engineering polymeric and hybrid microparticles as novel controlled release systems |
| title_full | Engineering polymeric and hybrid microparticles as novel controlled release systems |
| title_fullStr | Engineering polymeric and hybrid microparticles as novel controlled release systems |
| title_full_unstemmed | Engineering polymeric and hybrid microparticles as novel controlled release systems |
| title_short | Engineering polymeric and hybrid microparticles as novel controlled release systems |
| title_sort | engineering polymeric and hybrid microparticles as novel controlled release systems |
| topic | DRNTU::Engineering::Bioengineering |
| url | http://hdl.handle.net/10356/60829 |
| work_keys_str_mv | AT luodanielchinshiuan engineeringpolymericandhybridmicroparticlesasnovelcontrolledreleasesystems |