Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating
Cardiovascular disease remains on the top list of cause of death worldwide. Currently, the need for large diameter vascular graft are well-addressed by Dacron® and ePTFE synthetic graft. However, small diameter artificial vascular grafts remain an unmet clinical need. The advancement of vascular tis...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2014
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| Online Access: | http://hdl.handle.net/10356/61545 |
| _version_ | 1826112497350868992 |
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| author | Felix Fennardi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Felix Fennardi |
| author_sort | Felix Fennardi |
| collection | NTU |
| description | Cardiovascular disease remains on the top list of cause of death worldwide. Currently, the need for large diameter vascular graft are well-addressed by Dacron® and ePTFE synthetic graft. However, small diameter artificial vascular grafts remain an unmet clinical need. The advancement of vascular tissue engineering could provide a solution to artificially construct arterial prosthesis.
In vivo engineered biotube shows good promise in vascular tissue engineering due to ability of recruiting autologous cells and elimination of in vitro manipulation steps. The limitation was, however, poor cell attachment and structural integrity of the conduit to the silicone implanted tubing. The development of a coating that can promote cell attachment on the silicone tubing and is able to give mechanical support was proposed to address this problem.
Poly (lactide-co-glycolide) (PLGA) is a widely used bioresorbable polymer in biomedical applications. It exhibits good mechanical properties, is non-toxic, and has remarkable cytocompatibility. Keeping these superior properties in mind, PLGA films were fabricated using solvent casting and melt pressing method and their feasibility as a biotube coating was studied.
The results suggested PLGA films were promising for such application, in terms of mechanical properties and cytocompatibility. It is believed that the approach studied in this project could be potentially translated into clinical application in the future. |
| first_indexed | 2024-10-01T03:08:00Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/61545 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:08:00Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/615452023-03-03T15:33:01Z Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating Felix Fennardi School of Chemical and Biomedical Engineering DRNTU::Engineering Cardiovascular disease remains on the top list of cause of death worldwide. Currently, the need for large diameter vascular graft are well-addressed by Dacron® and ePTFE synthetic graft. However, small diameter artificial vascular grafts remain an unmet clinical need. The advancement of vascular tissue engineering could provide a solution to artificially construct arterial prosthesis. In vivo engineered biotube shows good promise in vascular tissue engineering due to ability of recruiting autologous cells and elimination of in vitro manipulation steps. The limitation was, however, poor cell attachment and structural integrity of the conduit to the silicone implanted tubing. The development of a coating that can promote cell attachment on the silicone tubing and is able to give mechanical support was proposed to address this problem. Poly (lactide-co-glycolide) (PLGA) is a widely used bioresorbable polymer in biomedical applications. It exhibits good mechanical properties, is non-toxic, and has remarkable cytocompatibility. Keeping these superior properties in mind, PLGA films were fabricated using solvent casting and melt pressing method and their feasibility as a biotube coating was studied. The results suggested PLGA films were promising for such application, in terms of mechanical properties and cytocompatibility. It is believed that the approach studied in this project could be potentially translated into clinical application in the future. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2014-06-11T06:59:34Z 2014-06-11T06:59:34Z 2014 2014 Final Year Project (FYP) http://hdl.handle.net/10356/61545 en Nanyang Technological University 58 p. application/pdf |
| spellingShingle | DRNTU::Engineering Felix Fennardi Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating |
| title | Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating |
| title_full | Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating |
| title_fullStr | Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating |
| title_full_unstemmed | Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating |
| title_short | Charactertization of poly (D, L-LACTIDE-CO-GLYCOLYDE) film for in vivo engineered biotube coating |
| title_sort | charactertization of poly d l lactide co glycolyde film for in vivo engineered biotube coating |
| topic | DRNTU::Engineering |
| url | http://hdl.handle.net/10356/61545 |
| work_keys_str_mv | AT felixfennardi charactertizationofpolydllactidecoglycolydefilmforinvivoengineeredbiotubecoating |